| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 26 | 26 | 11 | 6 | 3.07 | .277 | 1.13 | 7.7 | 2.4 | 10.4 | 173.0 | 148 | 65 | 59 | 16 | 47 | 199 | 0 | 0 | 0 | 0 | 18 | 4 | 3 | 2.79 |
| SP | Horton, C.Horton, Cade # >> | 23 | 2025 | R | 80 | 25 | 25 | 13 | 4 | 3.88 | .291 | 1.18 | 7.8 | 2.9 | 7.2 | 144.0 | 124 | 63 | 62 | 18 | 46 | 115 | 0 | 0 | 0 | 0 | 11 | 7 | 1 | 4.13 |
| RP | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 100 | 81 | 0 | 8 | 5 | 3.16 | .283 | 1.14 | 6.8 | 3.4 | 10.2 | 108.1 | 82 | 40 | 38 | 11 | 41 | 122 | 0 | 8 | 3 | 0 | 0 | 5 | 9 | 3.34 |
| RP | Jansen, K.Jansen, Kenley † >> | 37 | 2025 | R | 89 | 75 | 0 | 10 | 4 | 3.82 | .298 | 1.25 | 7.6 | 3.8 | 8.1 | 96.2 | 81 | 43 | 41 | 13 | 40 | 86 | 0 | 6 | 3 | 0 | 0 | 2 | 0 | 4.28 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 79 | 74 | 0 | 6 | 1 | 4.10 | .298 | 1.24 | 7.4 | 3.8 | 11.4 | 85.2 | 70 | 41 | 39 | 8 | 36 | 108 | 0 | 11 | 1 | 0 | 0 | 3 | 4 | 3.06 |
| RP | Abreu, B.Abreu, Bryan # >> | 28 | 2025 | R | 73 | 61 | 0 | 2 | 3 | 6.85 | .381 | 1.80 | 10.3 | 6.0 | 11.5 | 64.1 | 73 | 49 | 49 | 8 | 43 | 82 | 0 | 3 | 4 | 0 | 0 | 3 | 3 | 4.22 |
| RP | Santillan, T.Santillan, Tony >> | 28 | 2025 | R | 70 | 57 | 0 | 5 | 2 | 1.74 | .311 | 1.35 | 7.0 | 5.3 | 9.5 | 72.1 | 56 | 17 | 14 | 3 | 42 | 76 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.18 |