| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 15 | 15 | 10 | 4 | 2.27 | .248 | 0.98 | 6.1 | 2.8 | 9.8 | 107.0 | 72 | 31 | 27 | 5 | 33 | 117 | 1 | 0 | 0 | 1 | 11 | 1 | 2 | 2.37 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 88 | 15 | 15 | 6 | 4 | 4.38 | .298 | 1.25 | 7.7 | 3.7 | 8.7 | 96.2 | 82 | 50 | 47 | 15 | 39 | 93 | 1 | 0 | 0 | 1 | 8 | 2 | 1 | 4.38 |
| SP | Greinke, Z.Greinke, Zack # >> | 26 | 2009 | R | 76 | 16 | 15 | 6 | 3 | 4.84 | .330 | 1.46 | 9.4 | 3.7 | 9.1 | 89.1 | 93 | 48 | 48 | 12 | 37 | 90 | 0 | 0 | 0 | 0 | 8 | 2 | 1 | 4.04 |
| SP | Young, C.Young, Chris # >> | 28 | 2007 | R | 82 | 14 | 14 | 8 | 3 | 5.67 | .319 | 1.35 | 8.1 | 4.1 | 7.1 | 74.2 | 67 | 51 | 47 | 11 | 34 | 58 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 4.91 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 66 | 14 | 14 | 5 | 4 | 5.92 | .349 | 1.58 | 10.7 | 3.5 | 6.2 | 79.0 | 94 | 52 | 52 | 14 | 31 | 54 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 5.19 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 24 | 0 | 0 | 0 | 1.91 | .206 | 0.74 | 5.1 | 1.6 | 10.0 | 28.1 | 16 | 8 | 6 | 1 | 5 | 31 | 0 | 3 | 2 | 0 | 0 | 1 | 2 | 1.89 |
| RP | Percival, T.Percival, Troy >> | 38 | 2007 | R | 85 | 38 | 0 | 3 | 2 | 2.37 | .267 | 1.09 | 7.2 | 2.8 | 6.4 | 49.1 | 39 | 13 | 13 | 8 | 15 | 35 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 4.61 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 77 | 32 | 0 | 2 | 1 | 3.26 | .266 | 1.09 | 6.9 | 3.0 | 6.9 | 30.1 | 23 | 11 | 11 | 4 | 10 | 23 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.20 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 70 | 10 | 0 | 1 | 0 | 3.12 | .316 | 1.27 | 11.3 | 1.1 | 11.3 | 8.2 | 10 | 6 | 3 | 2 | 1 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.50 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 52 | 20 | 0 | 1 | 1 | 2.78 | .261 | 1.06 | 5.7 | 4.1 | 7.0 | 22.2 | 14 | 7 | 7 | 1 | 10 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.41 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 4 | 0 | 0 | 0 | 4.66 | .341 | 1.50 | 9.5 | 4.3 | 8.1 | 19.1 | 20 | 10 | 10 | 2 | 9 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.16 |