| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 14 | 14 | 5 | 5 | 2.96 | .282 | 1.14 | 7.5 | 2.9 | 10.8 | 94.1 | 78 | 32 | 31 | 10 | 30 | 113 | 2 | 0 | 0 | 2 | 9 | 3 | 1 | 3.03 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 86 | 16 | 16 | 6 | 6 | 4.75 | .312 | 1.33 | 10.1 | 1.9 | 8.3 | 102.1 | 115 | 54 | 54 | 16 | 21 | 94 | 3 | 0 | 0 | 1 | 9 | 3 | 5 | 3.90 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 16 | 15 | 4 | 7 | 6.32 | .343 | 1.51 | 8.8 | 4.9 | 6.7 | 74.0 | 72 | 52 | 52 | 13 | 40 | 55 | 1 | 0 | 0 | 0 | 6 | 4 | 1 | 5.58 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 44 | 0 | 1 | 1 | 3.69 | .280 | 1.17 | 7.9 | 2.7 | 8.4 | 63.1 | 55 | 26 | 26 | 5 | 19 | 59 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.06 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 36 | 0 | 0 | 2 | 4.95 | .385 | 1.88 | 9.5 | 7.4 | 11.3 | 40.0 | 42 | 22 | 22 | 6 | 33 | 50 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 4.93 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 33 | 0 | 5 | 3 | 4.21 | .355 | 1.54 | 9.8 | 4.3 | 7.8 | 36.1 | 39 | 18 | 17 | 9 | 17 | 31 | 0 | 2 | 4 | 0 | 0 | 4 | 0 | 6.28 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 28 | 0 | 0 | 3 | 7.27 | .328 | 1.46 | 9.3 | 3.8 | 11.4 | 26.0 | 27 | 23 | 21 | 7 | 11 | 33 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.23 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 52 | 25 | 0 | 1 | 1 | 4.33 | .325 | 1.37 | 7.0 | 5.3 | 12.3 | 27.0 | 21 | 13 | 13 | 6 | 16 | 37 | 0 | 0 | 2 | 0 | 0 | 2 | 1 | 5.15 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 15 | 2 | 1 | 6 | 4.12 | .326 | 1.42 | 10.6 | 2.3 | 5.3 | 39.1 | 46 | 18 | 18 | 6 | 10 | 23 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 4.67 |