| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 30 | 30 | 10 | 13 | 4.98 | .309 | 1.33 | 9.6 | 2.4 | 9.3 | 198.2 | 211 | 114 | 110 | 30 | 53 | 205 | 2 | 0 | 0 | 1 | 15 | 2 | 3 | 3.73 |
| SP | Oswalt, R.Oswalt, Roy # >> | 24 | 2001 | R | 71 | 29 | 29 | 6 | 10 | 4.29 | .315 | 1.36 | 9.8 | 2.5 | 8.4 | 153.0 | 166 | 75 | 73 | 23 | 42 | 143 | 0 | 0 | 0 | 0 | 9 | 3 | 0 | 3.97 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 49 | 28 | 28 | 10 | 15 | 6.37 | .357 | 1.64 | 11.7 | 3.1 | 5.9 | 155.1 | 201 | 110 | 110 | 28 | 53 | 101 | 0 | 0 | 0 | 0 | 9 | 5 | 6 | 5.17 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 28 | 28 | 4 | 9 | 6.45 | .378 | 1.82 | 10.2 | 6.2 | 6.3 | 127.0 | 144 | 97 | 91 | 13 | 87 | 89 | 0 | 0 | 0 | 0 | 4 | 1 | 8 | 5.01 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 83 | 0 | 1 | 9 | 5.52 | .334 | 1.48 | 10.5 | 2.8 | 8.5 | 101.0 | 118 | 70 | 62 | 21 | 31 | 95 | 0 | 11 | 7 | 0 | 0 | 3 | 0 | 4.83 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 70 | 0 | 1 | 6 | 4.99 | .333 | 1.43 | 8.4 | 4.5 | 8.0 | 74.0 | 69 | 41 | 41 | 9 | 37 | 66 | 0 | 3 | 4 | 0 | 0 | 5 | 1 | 4.50 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 35 | 69 | 0 | 5 | 2 | 5.84 | .355 | 1.62 | 9.8 | 4.8 | 9.5 | 77.0 | 84 | 50 | 50 | 16 | 41 | 81 | 0 | 7 | 1 | 0 | 0 | 2 | 6 | 5.27 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 23 | 54 | 0 | 3 | 3 | 6.07 | .362 | 1.69 | 11.3 | 4.0 | 10.9 | 56.1 | 70 | 43 | 38 | 10 | 25 | 68 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 4.29 |
| SP | Colon, B.Colon, Bartolo >> | 32 | 2005 | R | 22 | 36 | 0 | 6 | 1 | 4.15 | .331 | 1.45 | 10.8 | 2.4 | 6.8 | 60.2 | 72 | 28 | 28 | 7 | 16 | 45 | 0 | 4 | 0 | 0 | 0 | 2 | 2 | 3.92 |