| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 29 | 29 | 8 | 10 | 4.17 | .296 | 1.25 | 8.4 | 2.9 | 6.2 | 185.2 | 173 | 90 | 86 | 27 | 59 | 128 | 0 | 0 | 0 | 0 | 19 | 2 | 0 | 4.50 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 28 | 28 | 4 | 8 | 3.76 | .317 | 1.35 | 9.2 | 3.0 | 5.7 | 127.0 | 130 | 55 | 53 | 15 | 42 | 81 | 0 | 0 | 0 | 0 | 3 | 5 | 1 | 4.37 |
| SP | Burnett, A.Burnett, A.J. # >> | 25 | 2002 | R | 57 | 28 | 28 | 10 | 8 | 4.39 | .311 | 1.29 | 8.2 | 3.5 | 8.0 | 184.2 | 168 | 95 | 90 | 22 | 71 | 164 | 4 | 0 | 0 | 1 | 15 | 11 | 3 | 4.11 |
| SP | Harang, A.Harang, Aaron # >> | 29 | 2007 | R | 51 | 27 | 27 | 5 | 15 | 5.75 | .355 | 1.59 | 10.4 | 4.0 | 7.7 | 148.2 | 171 | 98 | 95 | 28 | 65 | 126 | 0 | 0 | 0 | 0 | 11 | 9 | 5 | 5.26 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 26 | 2006 | R | 93 | 68 | 0 | 7 | 4 | 2.90 | .270 | 1.08 | 7.1 | 2.7 | 10.2 | 105.2 | 83 | 35 | 34 | 8 | 31 | 119 | 0 | 1 | 4 | 0 | 0 | 3 | 0 | 2.70 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 72 | 0 | 4 | 5 | 3.56 | .297 | 1.24 | 8.5 | 2.7 | 7.5 | 98.2 | 93 | 39 | 39 | 8 | 29 | 82 | 0 | 6 | 4 | 0 | 0 | 3 | 2 | 3.37 |
| RP | Williamson, S.Williamson, Scott † >> | 26 | 2002 | R | 52 | 68 | 0 | 7 | 6 | 4.03 | .272 | 1.07 | 6.4 | 3.3 | 9.6 | 91.2 | 65 | 41 | 41 | 6 | 33 | 97 | 0 | 6 | 2 | 0 | 0 | 5 | 7 | 2.98 |
| RP | Donnelly, B.Donnelly, Brendan >> | 32 | 2003 | R | 40 | 57 | 0 | 0 | 5 | 4.36 | .288 | 1.17 | 7.5 | 3.0 | 8.6 | 74.1 | 62 | 38 | 36 | 8 | 25 | 71 | 0 | 7 | 3 | 0 | 0 | 3 | 1 | 3.62 |
| SP | Dempster, R.Dempster, Ryan >> | 31 | 2008 | R | 39 | 45 | 0 | 6 | 6 | 7.68 | .403 | 2.01 | 13.4 | 4.9 | 6.6 | 72.2 | 107 | 62 | 62 | 16 | 39 | 53 | 0 | 5 | 5 | 0 | 0 | 1 | 2 | 6.08 |