| SP | Lincecum, T.Lincecum, Tim † >> | 25 | 2009 | R | 92 | 29 | 29 | 12 | 8 | 3.86 | .306 | 1.29 | 7.8 | 3.8 | 8.0 | 186.1 | 161 | 83 | 80 | 12 | 79 | 165 | 2 | 0 | 0 | 1 | 17 | 6 | 9 | 3.44 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 87 | 28 | 28 | 14 | 9 | 3.35 | .282 | 1.16 | 7.8 | 2.7 | 6.9 | 207.0 | 180 | 79 | 77 | 27 | 61 | 158 | 6 | 0 | 0 | 1 | 20 | 3 | 3 | 4.10 |
| SP | Perez, O.Perez, Odalis # >> | 25 | 2002 | L | 81 | 28 | 28 | 14 | 5 | 3.15 | .266 | 1.06 | 8.2 | 1.4 | 6.2 | 186.0 | 169 | 72 | 65 | 20 | 29 | 128 | 0 | 0 | 0 | 0 | 20 | 4 | 5 | 3.55 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 28 | 28 | 8 | 5 | 4.55 | .308 | 1.32 | 9.4 | 2.5 | 6.4 | 128.2 | 134 | 65 | 65 | 18 | 36 | 91 | 0 | 0 | 0 | 0 | 8 | 2 | 2 | 4.30 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 27 | 26 | 5 | 9 | 6.45 | .355 | 1.62 | 9.7 | 5.0 | 7.4 | 104.2 | 112 | 77 | 75 | 14 | 58 | 86 | 0 | 0 | 0 | 0 | 2 | 3 | 0 | 4.86 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 63 | 0 | 3 | 6 | 2.22 | .225 | 0.87 | 6.7 | 1.2 | 9.7 | 69.0 | 51 | 17 | 17 | 6 | 9 | 74 | 0 | 37 | 5 | 0 | 0 | 0 | 1 | 2.38 |
| SU | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 85 | 60 | 0 | 1 | 1 | 3.32 | .256 | 0.97 | 5.4 | 3.3 | 8.7 | 65.0 | 39 | 24 | 24 | 9 | 24 | 63 | 0 | 6 | 3 | 0 | 0 | 4 | 3 | 4.15 |
| RP | Mantei, M.Mantei, Matt >> | 30 | 2003 | R | 60 | 54 | 0 | 6 | 0 | 2.31 | .255 | 1.01 | 6.4 | 2.8 | 9.3 | 62.1 | 44 | 17 | 16 | 6 | 19 | 64 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.16 |
| RP | Takatsu, S.Takatsu, Shingo >> | 36 | 2004 | R | 57 | 43 | 0 | 1 | 1 | 2.87 | .269 | 1.11 | 7.7 | 2.3 | 7.5 | 47.0 | 40 | 16 | 15 | 6 | 12 | 39 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 3.77 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 55 | 55 | 0 | 3 | 1 | 2.64 | .277 | 1.11 | 5.9 | 4.1 | 9.4 | 44.1 | 29 | 14 | 13 | 5 | 20 | 46 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 3.89 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 33 | 45 | 0 | 7 | 0 | 4.19 | .355 | 1.60 | 9.0 | 5.4 | 12.6 | 43.0 | 43 | 21 | 20 | 6 | 26 | 60 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.98 |