| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 98 | 16 | 16 | 4 | 7 | 5.04 | .341 | 1.52 | 9.1 | 4.7 | 9.1 | 69.2 | 70 | 39 | 39 | 7 | 36 | 70 | 0 | 0 | 0 | 0 | 1 | 2 | 8 | 3.94 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 87 | 16 | 16 | 9 | 4 | 4.66 | .315 | 1.35 | 10.5 | 1.7 | 6.7 | 119.2 | 139 | 63 | 62 | 16 | 23 | 88 | 3 | 0 | 0 | 0 | 5 | 3 | 5 | 3.92 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 15 | 15 | 2 | 4 | 6.11 | .351 | 1.55 | 9.9 | 4.1 | 6.6 | 84.0 | 92 | 58 | 57 | 14 | 38 | 62 | 1 | 0 | 0 | 0 | 7 | 6 | 2 | 5.26 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 15 | 15 | 7 | 8 | 4.79 | .323 | 1.41 | 10.0 | 2.7 | 7.4 | 103.1 | 115 | 58 | 55 | 13 | 31 | 85 | 2 | 0 | 0 | 0 | 6 | 2 | 1 | 3.95 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 80 | 39 | 0 | 1 | 2 | 3.14 | .299 | 1.26 | 6.5 | 4.9 | 11.1 | 51.2 | 37 | 19 | 18 | 5 | 28 | 63 | 0 | 8 | 0 | 0 | 0 | 1 | 1 | 3.51 |
| RP | Rodriguez, F.Rodriguez, Felix >> | 29 | 2001 | R | 59 | 33 | 0 | 4 | 1 | 2.50 | .283 | 1.16 | 6.5 | 4.2 | 8.5 | 39.2 | 28 | 13 | 11 | 4 | 18 | 37 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.90 |
| RP | Urbina, U.Urbina, Ugueth >> | 28 | 2002 | R | 44 | 28 | 0 | 1 | 3 | 3.73 | .304 | 1.28 | 8.4 | 3.2 | 11.3 | 31.1 | 29 | 18 | 13 | 3 | 11 | 39 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 2.90 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 1 | 0 | 0 | 1 | 20.25 | .600 | 4.50 | 27.0 | 27.0 | 9.0 | 1.1 | 3 | 3 | 3 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 10.00 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 3 | 0 | 0 | 1 | 6.23 | .333 | 1.50 | 12.4 | 2.3 | 11.3 | 8.2 | 11 | 6 | 6 | 2 | 2 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.50 |
| SP | Johnson, J.Johnson, Josh >> | 25 | 2009 | R | 47 | 17 | 0 | 2 | 2 | 6.11 | .350 | 1.58 | 10.3 | 4.1 | 6.7 | 35.1 | 40 | 26 | 24 | 8 | 16 | 26 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 5.94 |