| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 29 | 29 | 15 | 9 | 4.23 | .291 | 1.21 | 8.1 | 2.8 | 10.7 | 214.2 | 193 | 102 | 101 | 35 | 66 | 255 | 8 | 0 | 0 | 2 | 14 | 5 | 0 | 3.74 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 29 | 29 | 8 | 15 | 6.14 | .345 | 1.53 | 10.0 | 3.8 | 8.9 | 176.0 | 195 | 124 | 120 | 30 | 75 | 174 | 0 | 0 | 0 | 0 | 9 | 8 | 4 | 4.65 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 28 | 28 | 7 | 13 | 5.70 | .349 | 1.56 | 11.3 | 2.8 | 6.5 | 173.2 | 218 | 113 | 110 | 29 | 53 | 125 | 1 | 0 | 0 | 0 | 12 | 8 | 3 | 4.79 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 90 | 0 | 3 | 1 | 4.11 | .298 | 1.21 | 7.1 | 3.8 | 9.7 | 61.1 | 48 | 29 | 28 | 14 | 26 | 66 | 0 | 6 | 1 | 0 | 0 | 4 | 5 | 5.30 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 61 | 0 | 3 | 2 | 3.98 | .303 | 1.27 | 9.0 | 2.5 | 10.3 | 54.1 | 54 | 24 | 24 | 7 | 15 | 62 | 0 | 3 | 0 | 0 | 0 | 2 | 2 | 3.33 |
| RP | Wuertz, M.Wuertz, Michael † >> | 31 | 2009 | R | 73 | 72 | 0 | 9 | 2 | 3.63 | .309 | 1.29 | 7.8 | 3.8 | 10.3 | 62.0 | 54 | 27 | 25 | 4 | 26 | 71 | 0 | 6 | 4 | 0 | 0 | 3 | 5 | 2.95 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 56 | 0 | 4 | 4 | 2.39 | .302 | 1.26 | 6.9 | 4.6 | 11.1 | 67.2 | 51 | 19 | 18 | 6 | 34 | 83 | 0 | 7 | 2 | 0 | 0 | 3 | 3 | 3.34 |