| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 16 | 16 | 7 | 3 | 2.81 | .272 | 1.10 | 8.2 | 1.7 | 8.6 | 125.0 | 114 | 42 | 39 | 10 | 24 | 120 | 2 | 0 | 0 | 0 | 11 | 2 | 4 | 2.74 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 16 | 16 | 9 | 5 | 4.49 | .344 | 1.55 | 10.2 | 3.8 | 8.5 | 106.1 | 120 | 53 | 53 | 17 | 45 | 100 | 0 | 0 | 0 | 0 | 9 | 2 | 0 | 4.53 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 15 | 15 | 3 | 5 | 5.50 | .329 | 1.43 | 10.2 | 2.7 | 6.9 | 93.1 | 105 | 57 | 57 | 22 | 28 | 71 | 0 | 0 | 0 | 0 | 6 | 4 | 0 | 5.58 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 15 | 15 | 7 | 3 | 4.56 | .316 | 1.36 | 9.6 | 2.8 | 7.6 | 98.2 | 104 | 52 | 50 | 13 | 30 | 83 | 0 | 0 | 0 | 0 | 8 | 3 | 1 | 4.04 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 54 | 16 | 15 | 7 | 3 | 3.94 | .338 | 1.51 | 8.4 | 5.2 | 8.3 | 96.0 | 90 | 42 | 42 | 11 | 55 | 89 | 0 | 1 | 0 | 0 | 10 | 2 | 6 | 4.42 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 29 | 0 | 3 | 3 | 3.38 | .273 | 1.06 | 6.5 | 3.1 | 8.4 | 32.0 | 23 | 12 | 12 | 3 | 11 | 30 | 0 | 18 | 3 | 0 | 0 | 2 | 0 | 3.56 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 46 | 0 | 2 | 3 | 3.05 | .277 | 1.15 | 7.8 | 2.7 | 8.6 | 44.1 | 38 | 15 | 15 | 7 | 13 | 42 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.05 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 37 | 0 | 3 | 2 | 3.19 | .317 | 1.34 | 9.8 | 2.5 | 10.5 | 36.2 | 39 | 13 | 13 | 3 | 10 | 42 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 2.75 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 88 | 21 | 0 | 1 | 2 | 7.71 | .309 | 1.34 | 8.0 | 4.5 | 8.0 | 18.2 | 16 | 16 | 16 | 4 | 9 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.61 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 47 | 0 | 3 | 0 | 4.18 | .287 | 1.14 | 8.2 | 2.3 | 8.4 | 32.1 | 29 | 16 | 15 | 4 | 8 | 30 | 0 | 3 | 3 | 0 | 0 | 2 | 3 | 3.69 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 15 | 0 | 0 | 2 | 2.81 | .284 | 1.13 | 6.8 | 3.4 | 11.8 | 16.0 | 12 | 5 | 5 | 2 | 6 | 21 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 3.31 |