| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 22 | 22 | 8 | 6 | 4.27 | .281 | 1.16 | 7.9 | 2.5 | 8.7 | 124.1 | 109 | 60 | 59 | 16 | 35 | 120 | 4 | 0 | 0 | 1 | 8 | 2 | 5 | 3.64 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 20 | 20 | 8 | 8 | 5.07 | .296 | 1.24 | 9.3 | 1.8 | 4.8 | 110.0 | 114 | 63 | 62 | 15 | 22 | 59 | 3 | 0 | 0 | 1 | 5 | 3 | 0 | 4.38 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 20 | 20 | 8 | 7 | 3.36 | .265 | 1.08 | 7.7 | 2.0 | 6.1 | 115.1 | 99 | 45 | 43 | 6 | 25 | 78 | 3 | 0 | 0 | 1 | 8 | 1 | 0 | 3.00 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 20 | 20 | 6 | 3 | 5.42 | .320 | 1.41 | 9.1 | 3.7 | 5.0 | 86.1 | 87 | 55 | 52 | 13 | 35 | 48 | 2 | 0 | 0 | 0 | 5 | 0 | 1 | 5.07 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 36 | 0 | 0 | 1 | 2.61 | .271 | 1.10 | 7.9 | 2.1 | 7.9 | 48.1 | 42 | 14 | 14 | 5 | 11 | 42 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 3.35 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 39 | 0 | 2 | 5 | 3.79 | .283 | 1.16 | 8.1 | 2.4 | 9.5 | 38.0 | 34 | 16 | 16 | 5 | 10 | 40 | 0 | 22 | 3 | 0 | 0 | 1 | 0 | 3.47 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 46 | 0 | 1 | 3 | 3.88 | .327 | 1.46 | 9.9 | 3.3 | 8.0 | 60.1 | 66 | 29 | 26 | 5 | 22 | 53 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.42 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 24 | 0 | 1 | 3 | 4.20 | .326 | 1.40 | 8.6 | 4.3 | 4.1 | 40.2 | 38 | 23 | 19 | 3 | 19 | 18 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 4.65 |
| RP | O'Day, D.O'Day, Darren >> | 28 | 2010 | R | 50 | 18 | 0 | 3 | 1 | 4.58 | .330 | 1.47 | 9.5 | 4.3 | 3.8 | 19.2 | 20 | 10 | 10 | 1 | 9 | 8 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.26 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 52 | 16 | 0 | 0 | 0 | 9.92 | .329 | 1.47 | 11.3 | 2.3 | 6.8 | 16.1 | 20 | 18 | 18 | 4 | 4 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.50 |