| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 21 | 21 | 12 | 4 | 3.39 | .278 | 1.14 | 7.5 | 2.7 | 5.5 | 130.0 | 109 | 51 | 49 | 11 | 39 | 79 | 0 | 0 | 0 | 0 | 14 | 2 | 1 | 3.83 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 20 | 20 | 10 | 9 | 3.82 | .299 | 1.26 | 8.4 | 3.0 | 4.2 | 139.0 | 129 | 65 | 59 | 12 | 46 | 65 | 4 | 0 | 0 | 2 | 11 | 3 | 3 | 4.24 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 20 | 20 | 7 | 11 | 4.68 | .324 | 1.43 | 9.6 | 3.3 | 5.9 | 144.1 | 154 | 76 | 75 | 18 | 52 | 95 | 6 | 0 | 0 | 0 | 8 | 2 | 5 | 4.43 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 18 | 18 | 5 | 6 | 6.01 | .336 | 1.50 | 10.4 | 3.1 | 4.0 | 109.1 | 126 | 83 | 73 | 20 | 38 | 49 | 0 | 0 | 0 | 0 | 5 | 2 | 4 | 5.59 |
| RP | Papelbon, J.Papelbon, Jonathan † >> | 27 | 2007 | R | 92 | 54 | 0 | 6 | 1 | 3.71 | .284 | 1.15 | 7.7 | 2.6 | 8.3 | 68.0 | 58 | 29 | 28 | 6 | 20 | 63 | 0 | 6 | 4 | 0 | 0 | 3 | 0 | 3.31 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 16 | 0 | 0 | 1 | 5.29 | .393 | 1.88 | 11.1 | 5.8 | 8.5 | 17.0 | 21 | 10 | 10 | 6 | 11 | 16 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 7.82 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 21 | 0 | 1 | 0 | 2.08 | .222 | 0.86 | 4.8 | 3.0 | 9.9 | 30.1 | 16 | 7 | 7 | 1 | 10 | 33 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2.23 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 22 | 0 | 0 | 0 | 2.61 | .273 | 1.13 | 7.8 | 2.3 | 7.5 | 31.0 | 27 | 9 | 9 | 5 | 8 | 26 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.19 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 8 | 1 | 2 | 2 | 2.49 | .270 | 1.11 | 6.4 | 3.9 | 3.4 | 21.2 | 15 | 6 | 6 | 1 | 9 | 8 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4.14 |