| SP | McNally, D.McNally, Dave # >> | 26 | 1968 | L | 98 | 35 | 35 | 13 | 14 | 4.60 | .300 | 1.27 | 9.0 | 2.4 | 5.3 | 252.1 | 252 | 133 | 129 | 43 | 68 | 147 | 8 | 0 | 0 | 0 | 15 | 5 | 4 | 4.92 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 96 | 35 | 35 | 12 | 18 | 4.02 | .303 | 1.29 | 8.9 | 2.8 | 6.0 | 232.2 | 230 | 110 | 104 | 37 | 71 | 154 | 5 | 0 | 0 | 2 | 19 | 2 | 4 | 4.69 |
| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 93 | 35 | 35 | 18 | 9 | 3.88 | .290 | 1.21 | 7.8 | 3.1 | 9.0 | 231.2 | 201 | 102 | 100 | 30 | 79 | 232 | 2 | 0 | 0 | 1 | 23 | 4 | 1 | 3.76 |
| SP | deGrom, J.deGrom, Jacob >> | 30 | 2018 | R | 89 | 33 | 33 | 12 | 10 | 5.14 | .330 | 1.45 | 9.9 | 3.1 | 7.9 | 206.2 | 227 | 134 | 118 | 32 | 72 | 181 | 1 | 0 | 0 | 0 | 15 | 6 | 6 | 4.40 |
| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 72 | 33 | 33 | 15 | 11 | 4.91 | .309 | 1.33 | 9.0 | 3.1 | 9.5 | 209.0 | 208 | 121 | 114 | 37 | 71 | 221 | 4 | 0 | 0 | 0 | 15 | 2 | 0 | 4.23 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 97 | 75 | 0 | 12 | 4 | 2.35 | .214 | 0.82 | 4.6 | 2.8 | 8.4 | 88.0 | 45 | 23 | 23 | 4 | 27 | 82 | 0 | 37 | 6 | 0 | 0 | 0 | 1 | 2.65 |
| RP | Doolittle, S.Doolittle, Sean >> | 27 | 2014 | L | 93 | 85 | 0 | 2 | 2 | 2.59 | .239 | 0.94 | 5.4 | 3.1 | 7.7 | 90.1 | 54 | 26 | 26 | 10 | 31 | 77 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.77 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 75 | 61 | 0 | 5 | 1 | 4.42 | .352 | 1.61 | 9.2 | 5.3 | 8.2 | 59.0 | 60 | 31 | 29 | 9 | 35 | 54 | 0 | 3 | 4 | 0 | 0 | 1 | 1 | 4.98 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 79 | 21 | 0 | 2 | 3 | 6.32 | .345 | 1.54 | 10.9 | 3.0 | 5.2 | 57.0 | 69 | 40 | 40 | 12 | 19 | 33 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5.68 |