| SP | Guidry, R.Guidry, Ron † >> | 28 | 1978 | L | 83 | 34 | 34 | 19 | 9 | 3.52 | .288 | 1.18 | 7.6 | 3.0 | 6.0 | 245.1 | 208 | 102 | 96 | 18 | 82 | 163 | 12 | 0 | 0 | 5 | 19 | 7 | 4 | 3.71 |
| SP | Kershaw, C.Kershaw, Clayton # >> | 27 | 2015 | L | 92 | 33 | 32 | 15 | 14 | 3.54 | .281 | 1.15 | 7.9 | 2.5 | 8.7 | 226.1 | 198 | 95 | 89 | 33 | 63 | 218 | 5 | 0 | 0 | 1 | 21 | 4 | 6 | 3.86 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 100 | 59 | 0 | 6 | 2 | 1.89 | .206 | 0.78 | 4.8 | 2.3 | 8.9 | 66.2 | 35 | 18 | 14 | 7 | 17 | 65 | 0 | 25 | 5 | 0 | 0 | 0 | 0 | 3.18 |
| RP | Hernandez, W.Hernandez, Willie >> | 30 | 1984 | L | 56 | 56 | 0 | 5 | 2 | 4.35 | .305 | 1.30 | 7.9 | 3.9 | 4.9 | 51.2 | 45 | 25 | 25 | 7 | 22 | 28 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 5.04 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 89 | 32 | 0 | 0 | 1 | 3.16 | .230 | 0.89 | 5.8 | 2.3 | 9.0 | 31.1 | 20 | 12 | 11 | 3 | 8 | 31 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 3.03 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 81 | 63 | 0 | 3 | 5 | 3.56 | .314 | 1.35 | 6.8 | 5.4 | 9.6 | 48.0 | 36 | 20 | 19 | 6 | 29 | 51 | 0 | 2 | 0 | 0 | 0 | 1 | 4 | 4.38 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 87 | 56 | 0 | 3 | 1 | 4.44 | .295 | 1.25 | 6.9 | 4.5 | 8.6 | 48.2 | 37 | 25 | 24 | 9 | 24 | 46 | 0 | 2 | 0 | 0 | 0 | 0 | 6 | 5.02 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 59 | 20 | 18 | 6 | 9 | 4.88 | .279 | 1.14 | 7.4 | 2.8 | 8.5 | 118.0 | 97 | 67 | 64 | 23 | 37 | 111 | 2 | 0 | 0 | 1 | 12 | 3 | 4 | 4.67 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 84 | 21 | 12 | 5 | 9 | 4.53 | .295 | 1.26 | 8.4 | 3.0 | 4.9 | 115.1 | 107 | 61 | 58 | 19 | 38 | 63 | 4 | 0 | 0 | 0 | 6 | 0 | 2 | 5.04 |