| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 24 | 24 | 7 | 14 | 3.99 | .303 | 1.29 | 8.7 | 2.9 | 5.3 | 171.1 | 165 | 82 | 76 | 18 | 56 | 101 | 5 | 0 | 0 | 1 | 13 | 2 | 1 | 4.20 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 22 | 22 | 9 | 11 | 4.77 | .304 | 1.31 | 8.3 | 3.4 | 5.8 | 149.0 | 138 | 85 | 79 | 30 | 57 | 96 | 6 | 0 | 0 | 2 | 11 | 0 | 1 | 5.48 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 22 | 22 | 7 | 11 | 4.35 | .309 | 1.31 | 8.9 | 2.9 | 4.3 | 165.1 | 163 | 84 | 80 | 20 | 54 | 78 | 8 | 0 | 0 | 2 | 11 | 5 | 4 | 4.70 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 58 | 0 | 3 | 2 | 3.89 | .290 | 1.23 | 8.6 | 2.5 | 10.8 | 71.2 | 68 | 36 | 31 | 7 | 20 | 85 | 0 | 6 | 4 | 0 | 0 | 0 | 0 | 2.73 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 46 | 0 | 3 | 6 | 5.12 | .328 | 1.47 | 8.7 | 4.5 | 4.8 | 58.0 | 56 | 34 | 33 | 8 | 29 | 31 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 5.22 |
| RP | Rhodes, A.Rhodes, Arthur # >> | 32 | 2001 | L | 64 | 31 | 0 | 1 | 4 | 6.55 | .377 | 1.79 | 12.0 | 4.1 | 8.5 | 33.0 | 44 | 24 | 24 | 6 | 15 | 31 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 4.94 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 24 | 0 | 1 | 2 | 4.32 | .375 | 1.71 | 9.0 | 6.5 | 7.1 | 33.1 | 33 | 17 | 16 | 1 | 24 | 26 | 0 | 1 | 2 | 0 | 0 | 3 | 2 | 4.27 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 57 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | 18.0 | 0.0 | 27.0 | 1.1 | 2 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -3.00 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 12 | 0 | 1 | 1 | 4.76 | .366 | 1.73 | 11.6 | 4.2 | 6.1 | 28.1 | 36 | 24 | 15 | 5 | 13 | 19 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 5.36 |