| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 17 | 13 | 4.39 | .290 | 1.20 | 8.9 | 1.9 | 7.6 | 254.1 | 251 | 130 | 124 | 32 | 55 | 215 | 7 | 0 | 0 | 2 | 19 | 6 | 12 | 3.67 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 8 | 14 | 5.00 | .327 | 1.43 | 10.4 | 2.5 | 8.8 | 199.2 | 231 | 118 | 111 | 27 | 55 | 194 | 1 | 0 | 0 | 0 | 15 | 5 | 2 | 3.72 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 32 | 32 | 10 | 18 | 6.45 | .348 | 1.60 | 10.5 | 3.9 | 6.3 | 206.2 | 241 | 151 | 148 | 35 | 90 | 144 | 3 | 0 | 0 | 1 | 8 | 0 | 2 | 5.12 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 31 | 31 | 11 | 15 | 4.66 | .316 | 1.38 | 9.5 | 2.9 | 4.6 | 253.0 | 268 | 143 | 131 | 23 | 81 | 128 | 11 | 0 | 0 | 3 | 11 | 2 | 3 | 4.15 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 88 | 0 | 2 | 4 | 2.56 | .254 | 1.01 | 6.6 | 2.6 | 8.7 | 119.2 | 87 | 42 | 34 | 14 | 34 | 115 | 0 | 7 | 4 | 0 | 0 | 1 | 3 | 3.48 |
| RP | Bautista, F.Bautista, Félix # >> | 28 | 2023 | R | 75 | 51 | 0 | 4 | 5 | 5.18 | .354 | 1.62 | 6.9 | 7.9 | 10.7 | 48.2 | 37 | 30 | 28 | 8 | 42 | 57 | 0 | 2 | 3 | 0 | 0 | 1 | 5 | 5.48 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 44 | 0 | 2 | 4 | 3.86 | .313 | 1.35 | 9.0 | 3.1 | 7.2 | 49.0 | 49 | 26 | 21 | 7 | 17 | 39 | 0 | 2 | 3 | 0 | 0 | 1 | 3 | 4.37 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 1 | 0 | 0 | 0 | 27.00 | .500 | 3.00 | - | - | - | 0.2 | 2 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 27 | 0 | 2 | 2 | 4.89 | .328 | 1.46 | 9.4 | 3.9 | 4.3 | 42.1 | 44 | 28 | 23 | 3 | 18 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.26 |