| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 93 | 38 | 38 | 15 | 12 | 4.14 | .285 | 1.19 | 8.2 | 2.5 | 5.6 | 241.1 | 219 | 117 | 111 | 31 | 67 | 149 | 6 | 0 | 0 | 2 | 20 | 3 | 12 | 4.31 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 39 | 39 | 14 | 18 | 4.39 | .307 | 1.31 | 8.5 | 3.3 | 7.2 | 242.0 | 229 | 122 | 118 | 25 | 89 | 193 | 5 | 0 | 0 | 1 | 21 | 3 | 2 | 3.89 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 36 | 36 | 13 | 12 | 4.58 | .296 | 1.25 | 8.9 | 2.4 | 4.9 | 212.1 | 210 | 111 | 108 | 24 | 56 | 116 | 5 | 0 | 0 | 3 | 17 | 2 | 4 | 4.20 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 30 | 30 | 12 | 10 | 4.83 | .336 | 1.50 | 8.4 | 5.1 | 8.8 | 162.0 | 151 | 90 | 87 | 16 | 92 | 158 | 0 | 0 | 0 | 0 | 13 | 3 | 2 | 4.09 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 94 | 0 | 7 | 1 | 2.63 | .286 | 1.16 | 6.2 | 4.3 | 7.6 | 109.2 | 75 | 34 | 32 | 5 | 52 | 92 | 0 | 6 | 1 | 0 | 0 | 5 | 4 | 3.48 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 79 | 0 | 9 | 3 | 4.05 | .286 | 1.16 | 7.0 | 3.5 | 7.7 | 102.1 | 79 | 48 | 46 | 10 | 40 | 87 | 0 | 9 | 4 | 0 | 0 | 4 | 3 | 3.86 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 72 | 0 | 4 | 1 | 4.43 | .307 | 1.30 | 7.7 | 4.1 | 9.2 | 81.1 | 69 | 40 | 40 | 8 | 37 | 83 | 0 | 11 | 0 | 0 | 0 | 2 | 2 | 3.68 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 51 | 0 | 4 | 0 | 2.97 | .248 | 0.99 | 6.0 | 3.0 | 9.9 | 60.2 | 40 | 22 | 20 | 4 | 20 | 66 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 2.67 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 4 | 0 | 1 | 0 | 2.16 | .306 | 1.20 | 6.8 | 4.5 | 2.3 | 8.1 | 6 | 2 | 2 | 1 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6.00 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 27 | 0 | 3 | 5 | 7.62 | .361 | 1.69 | 12.7 | 2.6 | 4.8 | 41.1 | 58 | 38 | 35 | 8 | 12 | 22 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 5.34 |