| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 23 | 23 | 12 | 4 | 3.02 | .283 | 1.17 | 7.2 | 3.3 | 6.3 | 149.0 | 119 | 51 | 50 | 8 | 55 | 105 | 0 | 0 | 0 | 0 | 14 | 2 | 2 | 3.44 |
| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 97 | 23 | 23 | 10 | 6 | 3.70 | .286 | 1.18 | 7.9 | 2.8 | 7.6 | 175.1 | 153 | 74 | 72 | 18 | 54 | 148 | 9 | 0 | 0 | 0 | 13 | 4 | 3 | 3.64 |
| RP | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 94 | 67 | 0 | 6 | 0 | 2.32 | .253 | 1.00 | 5.7 | 3.3 | 9.8 | 66.0 | 42 | 18 | 17 | 5 | 24 | 72 | 0 | 3 | 0 | 0 | 0 | 1 | 2 | 2.94 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 64 | 0 | 2 | 2 | 3.86 | .281 | 1.17 | 7.0 | 3.7 | 7.5 | 53.2 | 41 | 24 | 23 | 6 | 22 | 44 | 0 | 5 | 5 | 0 | 0 | 0 | 0 | 4.06 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 57 | 0 | 3 | 2 | 4.89 | .326 | 1.42 | 8.5 | 4.5 | 9.0 | 38.2 | 36 | 21 | 21 | 8 | 19 | 38 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 5.32 |
| RP | Bautista, F.Bautista, Félix # >> | 28 | 2023 | R | 75 | 64 | 0 | 1 | 1 | 5.79 | .355 | 1.56 | 9.6 | 4.8 | 11.5 | 32.2 | 34 | 21 | 21 | 6 | 17 | 41 | 0 | 5 | 1 | 0 | 0 | 3 | 6 | 4.75 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 33 | 51 | 0 | 5 | 2 | 2.12 | .266 | 1.06 | 6.4 | 3.2 | 9.3 | 34.0 | 24 | 8 | 8 | 0 | 12 | 35 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 2.09 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 46 | 0 | 4 | 2 | 3.60 | .280 | 1.10 | 5.7 | 4.2 | 10.2 | 30.0 | 19 | 12 | 12 | 1 | 14 | 34 | 0 | 6 | 0 | 0 | 0 | 2 | 1 | 2.77 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 36 | 35 | 0 | 2 | 2 | 2.41 | .273 | 1.13 | 4.1 | 6.3 | 8.5 | 33.2 | 15 | 9 | 9 | 1 | 23 | 31 | 0 | 6 | 0 | 0 | 0 | 0 | 1 | 3.61 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 30 | 0 | 2 | 0 | 6.15 | .313 | 1.37 | 7.6 | 4.8 | 10.0 | 26.1 | 22 | 18 | 18 | 2 | 14 | 29 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.38 |