| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 36 | 36 | 14 | 14 | 3.41 | .281 | 1.16 | 7.9 | 2.6 | 8.1 | 290.1 | 253 | 116 | 110 | 29 | 83 | 262 | 12 | 0 | 0 | 2 | 23 | 4 | 8 | 3.39 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 34 | 34 | 9 | 17 | 4.63 | .314 | 1.35 | 9.0 | 3.1 | 4.9 | 192.1 | 193 | 105 | 99 | 17 | 67 | 105 | 0 | 0 | 0 | 0 | 18 | 4 | 4 | 4.17 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 47 | 27 | 27 | 12 | 8 | 4.45 | .317 | 1.36 | 8.6 | 3.6 | 8.1 | 166.0 | 158 | 85 | 82 | 17 | 67 | 150 | 1 | 0 | 0 | 0 | 17 | 6 | 2 | 3.84 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 34 | 33 | 15 | 15 | 4.39 | .308 | 1.31 | 8.9 | 2.9 | 5.6 | 227.1 | 225 | 115 | 111 | 27 | 73 | 140 | 8 | 0 | 0 | 2 | 17 | 6 | 4 | 4.36 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 24 | 24 | 7 | 9 | 5.13 | .320 | 1.40 | 8.8 | 3.9 | 5.8 | 144.0 | 140 | 85 | 82 | 20 | 62 | 93 | 0 | 0 | 0 | 0 | 10 | 1 | 5 | 4.83 |
| RP | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 100 | 0 | 5 | 0 | 2.38 | .267 | 1.08 | 5.6 | 4.1 | 11.6 | 83.1 | 52 | 22 | 22 | 2 | 38 | 107 | 0 | 3 | 0 | 0 | 0 | 1 | 4 | 2.14 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 80 | 0 | 5 | 3 | 2.89 | .255 | 1.01 | 6.0 | 3.2 | 10.8 | 65.1 | 43 | 22 | 21 | 4 | 23 | 78 | 0 | 7 | 3 | 0 | 0 | 1 | 0 | 2.51 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 49 | 85 | 0 | 2 | 2 | 3.79 | .285 | 1.14 | 7.9 | 2.4 | 8.1 | 57.0 | 50 | 24 | 24 | 4 | 15 | 51 | 0 | 4 | 2 | 0 | 0 | 3 | 0 | 3.07 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 26 | 0 | 2 | 5 | 5.09 | .296 | 1.22 | 7.4 | 3.5 | 9.4 | 23.0 | 19 | 13 | 13 | 3 | 9 | 24 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 3.91 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 83 | 29 | 8 | 6 | 5 | 5.36 | .324 | 1.40 | 11.2 | 1.4 | 5.0 | 102.1 | 127 | 63 | 61 | 11 | 16 | 57 | 1 | 0 | 1 | 0 | 2 | 4 | 1 | 3.87 |