| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 10 | 14 | 4.40 | .313 | 1.36 | 9.4 | 2.9 | 8.9 | 210.2 | 219 | 109 | 103 | 23 | 67 | 207 | 1 | 0 | 0 | 0 | 17 | 2 | 0 | 3.44 |
| SP | Kluber, C.Kluber, Corey † # >> | 31 | 2017 | R | 89 | 33 | 33 | 12 | 11 | 3.98 | .287 | 1.19 | 8.3 | 2.4 | 8.5 | 233.0 | 215 | 111 | 103 | 31 | 63 | 221 | 7 | 0 | 0 | 1 | 21 | 4 | 4 | 3.70 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 32 | 32 | 13 | 15 | 5.15 | .324 | 1.44 | 9.7 | 3.2 | 4.5 | 213.0 | 230 | 129 | 122 | 33 | 76 | 106 | 2 | 0 | 0 | 1 | 16 | 0 | 1 | 5.09 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 32 | 32 | 11 | 14 | 5.18 | .337 | 1.52 | 9.9 | 3.8 | 6.2 | 232.2 | 255 | 139 | 134 | 33 | 98 | 161 | 6 | 0 | 0 | 2 | 12 | 2 | 7 | 4.75 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 85 | 0 | 5 | 5 | 3.97 | .274 | 1.12 | 7.4 | 2.7 | 8.8 | 104.1 | 86 | 47 | 46 | 12 | 31 | 102 | 0 | 13 | 5 | 0 | 0 | 1 | 2 | 3.46 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 66 | 0 | 1 | 5 | 3.97 | .332 | 1.46 | 8.0 | 5.3 | 8.4 | 70.1 | 62 | 31 | 31 | 13 | 41 | 65 | 0 | 7 | 0 | 0 | 0 | 2 | 0 | 5.40 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 67 | 48 | 0 | 5 | 0 | 4.89 | .302 | 1.26 | 8.2 | 3.2 | 7.1 | 57.0 | 52 | 32 | 31 | 6 | 20 | 45 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 3.95 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 4 | 0 | 0 | 0 | 18.00 | .538 | 3.50 | 15.8 | 15.8 | 4.5 | 4.0 | 7 | 8 | 8 | 1 | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.50 |