| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 23 | 23 | 14 | 5 | 2.95 | .257 | 1.01 | 6.7 | 2.4 | 8.9 | 155.1 | 115 | 52 | 51 | 19 | 42 | 153 | 1 | 0 | 0 | 1 | 18 | 4 | 0 | 3.51 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 83 | 23 | 23 | 7 | 8 | 4.37 | .279 | 1.10 | 8.3 | 1.7 | 5.3 | 146.1 | 134 | 76 | 71 | 22 | 27 | 86 | 6 | 0 | 0 | 1 | 11 | 9 | 0 | 4.52 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 59 | 0 | 5 | 1 | 2.30 | .267 | 1.09 | 5.5 | 4.4 | 8.1 | 70.1 | 43 | 19 | 18 | 2 | 34 | 63 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.03 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 48 | 0 | 3 | 4 | 2.93 | .246 | 0.95 | 5.6 | 3.0 | 8.1 | 61.1 | 38 | 20 | 20 | 7 | 20 | 55 | 0 | 10 | 2 | 0 | 0 | 2 | 1 | 3.77 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 28 | 0 | 3 | 2 | 2.41 | .252 | 0.95 | 4.9 | 3.8 | 10.6 | 33.2 | 18 | 9 | 9 | 4 | 14 | 39 | 0 | 2 | 2 | 0 | 0 | 2 | 5 | 3.67 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 21 | 0 | 2 | 1 | 2.73 | .295 | 1.25 | 7.6 | 3.8 | 6.6 | 26.1 | 22 | 8 | 8 | 3 | 11 | 19 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 22 | 0 | 2 | 2 | 2.38 | .261 | 1.03 | 4.8 | 4.5 | 8.2 | 34.0 | 18 | 9 | 9 | 1 | 17 | 31 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.15 |