| SP | Greinke, Z.Greinke, Zack # $ >> | 32 | 2015 | R | 94 | 26 | 26 | 6 | 6 | 5.00 | .316 | 1.35 | 9.2 | 3.0 | 5.5 | 145.2 | 149 | 93 | 81 | 14 | 48 | 88 | 2 | 0 | 0 | 1 | 12 | 5 | 2 | 4.14 |
| SP | Richard, J.Richard, J.R. $$ >> | 30 | 1980 | R | 90 | 24 | 24 | 10 | 3 | 4.52 | .318 | 1.39 | 8.2 | 4.4 | 8.0 | 141.1 | 128 | 72 | 71 | 11 | 69 | 126 | 1 | 0 | 0 | 1 | 12 | 1 | 2 | 3.72 |
| SP | Alexander, P.Alexander, Pete $$ >> | 28 | 1915 | R | 88 | 24 | 24 | 11 | 8 | 3.73 | .297 | 1.25 | 8.0 | 3.3 | 4.9 | 149.2 | 133 | 67 | 62 | 11 | 54 | 81 | 5 | 0 | 0 | 0 | 14 | 3 | 0 | 4.02 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 85 | 55 | 0 | 9 | 2 | 3.74 | .286 | 1.18 | 8.0 | 2.6 | 7.6 | 65.0 | 58 | 28 | 27 | 12 | 19 | 55 | 0 | 13 | 5 | 0 | 0 | 1 | 2 | 4.63 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 54 | 0 | 7 | 3 | 4.20 | .302 | 1.27 | 7.8 | 3.6 | 5.7 | 60.0 | 52 | 28 | 28 | 11 | 24 | 38 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.42 |
| RP | Treinen, B.Treinen, Blake $ >> | 30 | 2018 | R | 79 | 43 | 0 | 3 | 1 | 2.83 | .299 | 1.28 | 7.5 | 4.2 | 8.6 | 47.2 | 39 | 15 | 15 | 5 | 22 | 45 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.87 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 39 | 0 | 3 | 0 | 2.66 | .265 | 1.08 | 7.4 | 2.5 | 7.9 | 40.2 | 33 | 12 | 12 | 2 | 11 | 35 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.73 |
| CL | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 67 | 0 | 6 | 6 | 2.14 | .243 | 0.95 | 5.6 | 2.9 | 7.7 | 80.0 | 50 | 20 | 19 | 6 | 26 | 68 | 0 | 13 | 5 | 0 | 0 | 1 | 3 | 3.29 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 42 | 0 | 1 | 1 | 1.72 | .256 | 1.01 | 5.5 | 3.6 | 8.5 | 52.1 | 32 | 11 | 10 | 3 | 21 | 49 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.13 |