| SP | Walsh, E.Walsh, Ed † $$ >> | 29 | 1910 | R | 93 | 31 | 31 | 19 | 7 | 3.01 | .259 | 1.03 | 6.7 | 2.6 | 4.1 | 221.1 | 164 | 76 | 74 | 17 | 65 | 101 | 10 | 0 | 0 | 2 | 23 | 3 | 5 | 4.01 |
| SP | Snell, B.Snell, Blake $ >> | 25 | 2018 | L | 80 | 30 | 30 | 17 | 6 | 3.13 | .285 | 1.18 | 6.4 | 4.2 | 7.7 | 181.0 | 129 | 64 | 63 | 13 | 84 | 155 | 0 | 0 | 0 | 0 | 19 | 3 | 2 | 3.66 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 70 | 30 | 30 | 9 | 13 | 5.06 | .320 | 1.37 | 9.1 | 3.3 | 7.2 | 185.0 | 187 | 114 | 104 | 28 | 67 | 148 | 1 | 0 | 0 | 1 | 14 | 7 | 6 | 4.57 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 30 | 29 | 9 | 13 | 5.17 | .336 | 1.50 | 8.8 | 4.7 | 5.5 | 172.1 | 168 | 106 | 99 | 19 | 90 | 105 | 1 | 0 | 0 | 1 | 10 | 4 | 8 | 4.85 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 74 | 0 | 4 | 1 | 4.48 | .293 | 1.19 | 8.4 | 2.3 | 8.9 | 92.1 | 86 | 50 | 46 | 12 | 24 | 91 | 0 | 1 | 5 | 0 | 0 | 5 | 3 | 3.66 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 55 | 0 | 4 | 1 | 5.14 | .336 | 1.50 | 9.6 | 4.0 | 8.0 | 61.1 | 65 | 35 | 35 | 10 | 27 | 54 | 0 | 2 | 1 | 0 | 0 | 1 | 4 | 4.74 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 42 | 0 | 3 | 4 | 4.89 | .313 | 1.37 | 10.0 | 2.3 | 7.4 | 46.0 | 51 | 25 | 25 | 6 | 12 | 38 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.83 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 31 | 0 | 0 | 0 | 3.46 | .299 | 1.28 | 6.7 | 4.8 | 5.8 | 39.0 | 29 | 18 | 15 | 3 | 21 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.33 |
| CL | Street, H.Street, Huston † $ >> | 29 | 2012 | R | 96 | 68 | 0 | 6 | 6 | 2.86 | .281 | 1.16 | 6.8 | 3.8 | 7.6 | 72.1 | 54 | 24 | 23 | 6 | 30 | 61 | 0 | 36 | 4 | 0 | 0 | 1 | 2 | 3.68 |