| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 27 | 27 | 10 | 10 | 3.57 | .288 | 1.20 | 7.9 | 2.9 | 6.8 | 194.1 | 171 | 83 | 77 | 21 | 62 | 146 | 2 | 0 | 0 | 0 | 17 | 3 | 3 | 3.91 |
| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 92 | 27 | 27 | 17 | 5 | 3.19 | .301 | 1.28 | 8.4 | 3.2 | 4.9 | 214.2 | 199 | 81 | 76 | 20 | 75 | 116 | 10 | 0 | 0 | 1 | 19 | 3 | 2 | 4.22 |
| SP | Mathewson, C.Mathewson, Christy # >> | 28 | 1908 | R | 82 | 26 | 26 | 10 | 9 | 3.87 | .270 | 1.08 | 8.0 | 1.8 | 4.9 | 181.1 | 160 | 86 | 78 | 21 | 36 | 98 | 4 | 0 | 0 | 0 | 13 | 5 | 0 | 4.10 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 26 | 26 | 10 | 10 | 3.66 | .288 | 1.19 | 7.2 | 3.6 | 4.5 | 184.2 | 147 | 81 | 75 | 19 | 73 | 91 | 5 | 0 | 0 | 3 | 16 | 4 | 5 | 4.61 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 62 | 0 | 7 | 3 | 3.91 | .257 | 0.99 | 6.6 | 2.4 | 8.0 | 89.2 | 65 | 44 | 39 | 14 | 24 | 79 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 4.21 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 31 | 0 | 5 | 1 | 3.00 | .277 | 1.15 | 7.6 | 2.7 | 4.6 | 33.0 | 28 | 11 | 11 | 1 | 10 | 17 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.27 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 18 | 0 | 2 | 1 | 1.44 | .194 | 0.72 | 2.5 | 4.0 | 9.7 | 25.0 | 7 | 4 | 4 | 1 | 11 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.68 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 11 | 0 | 1 | 0 | 5.51 | .300 | 1.29 | 9.0 | 2.8 | 9.0 | 16.1 | 16 | 10 | 10 | 2 | 5 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.56 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 43 | 0 | 0 | 2 | 2.09 | .314 | 1.32 | 6.6 | 5.4 | 8.5 | 38.2 | 28 | 11 | 9 | 2 | 23 | 36 | 0 | 37 | 3 | 0 | 0 | 2 | 2 | 3.76 |