| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 27 | 27 | 12 | 8 | 3.55 | .296 | 1.23 | 8.3 | 2.8 | 9.2 | 157.0 | 145 | 65 | 62 | 14 | 48 | 160 | 0 | 0 | 0 | 0 | 15 | 5 | 0 | 3.13 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 26 | 26 | 11 | 6 | 3.79 | .307 | 1.32 | 8.1 | 3.8 | 11.0 | 152.0 | 136 | 65 | 64 | 15 | 65 | 185 | 2 | 0 | 0 | 1 | 14 | 1 | 5 | 3.15 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 26 | 26 | 14 | 8 | 4.32 | .323 | 1.41 | 9.2 | 3.5 | 7.0 | 160.1 | 163 | 81 | 77 | 18 | 63 | 125 | 2 | 0 | 0 | 1 | 14 | 3 | 3 | 4.14 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 26 | 26 | 13 | 9 | 4.06 | .305 | 1.31 | 9.3 | 2.5 | 8.4 | 162.0 | 167 | 73 | 73 | 18 | 45 | 152 | 2 | 0 | 0 | 0 | 16 | 1 | 8 | 3.42 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 24 | 24 | 12 | 9 | 3.97 | .283 | 1.18 | 8.5 | 2.1 | 5.4 | 172.1 | 163 | 80 | 76 | 23 | 40 | 104 | 7 | 0 | 0 | 0 | 14 | 1 | 4 | 4.24 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 64 | 0 | 2 | 4 | 4.09 | .270 | 1.11 | 6.9 | 3.1 | 9.5 | 70.1 | 54 | 33 | 32 | 5 | 24 | 74 | 0 | 35 | 4 | 0 | 0 | 0 | 3 | 2.84 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 71 | 0 | 2 | 2 | 3.17 | .265 | 1.06 | 6.0 | 3.6 | 7.9 | 76.2 | 51 | 28 | 27 | 8 | 30 | 67 | 0 | 0 | 4 | 0 | 0 | 2 | 0 | 3.87 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 70 | 0 | 6 | 0 | 4.40 | .326 | 1.41 | 9.4 | 3.5 | 10.8 | 75.2 | 78 | 40 | 37 | 11 | 29 | 90 | 0 | 2 | 2 | 0 | 0 | 3 | 2 | 3.79 |
| RP | Gallegos, G.Gallegos, Giovanny # >> | 27 | 2019 | R | 81 | 52 | 0 | 5 | 2 | 6.63 | .350 | 1.60 | 10.7 | 3.6 | 8.7 | 57.0 | 68 | 43 | 42 | 15 | 23 | 55 | 0 | 1 | 4 | 0 | 0 | 1 | 4 | 5.75 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 44 | 0 | 2 | 1 | 4.05 | .283 | 1.16 | 8.9 | 1.6 | 7.5 | 66.2 | 65 | 32 | 30 | 6 | 12 | 55 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.15 |