| SP | Arrieta, J.Arrieta, Jake $ >> | 29 | 2015 | R | 95 | 28 | 28 | 9 | 9 | 3.35 | .288 | 1.18 | 7.8 | 2.9 | 8.7 | 188.1 | 162 | 70 | 70 | 16 | 60 | 182 | 1 | 0 | 0 | 0 | 19 | 6 | 2 | 3.22 |
| SP | McClanahan, S.McClanahan, Shane # >> | 25 | 2022 | L | 90 | 27 | 27 | 4 | 10 | 5.25 | .305 | 1.26 | 8.9 | 2.5 | 8.0 | 142.1 | 140 | 87 | 83 | 29 | 40 | 127 | 1 | 0 | 0 | 0 | 11 | 7 | 3 | 4.86 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 85 | 26 | 26 | 10 | 11 | 4.46 | .320 | 1.39 | 9.3 | 3.3 | 8.4 | 137.1 | 141 | 76 | 68 | 18 | 50 | 128 | 0 | 0 | 0 | 0 | 13 | 3 | 2 | 4.00 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 79 | 26 | 26 | 9 | 13 | 4.38 | .294 | 1.21 | 8.7 | 2.2 | 8.9 | 166.1 | 161 | 82 | 81 | 24 | 40 | 165 | 3 | 0 | 0 | 0 | 16 | 7 | 4 | 3.74 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 71 | 27 | 26 | 7 | 12 | 4.88 | .329 | 1.44 | 9.4 | 3.5 | 7.1 | 142.0 | 149 | 80 | 77 | 21 | 55 | 112 | 1 | 0 | 0 | 0 | 13 | 5 | 1 | 4.61 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 93 | 73 | 0 | 2 | 1 | 2.34 | .280 | 1.10 | 4.6 | 5.3 | 10.7 | 69.1 | 35 | 18 | 18 | 2 | 41 | 82 | 0 | 0 | 1 | 0 | 0 | 5 | 4 | 3.00 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 86 | 52 | 0 | 2 | 3 | 5.92 | .324 | 1.42 | 8.6 | 4.3 | 8.4 | 48.2 | 46 | 33 | 32 | 6 | 23 | 45 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 4.25 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 76 | 50 | 0 | 1 | 2 | 3.00 | .259 | 1.05 | 5.5 | 3.9 | 6.9 | 39.0 | 24 | 13 | 13 | 5 | 17 | 30 | 0 | 0 | 3 | 0 | 0 | 0 | 2 | 4.44 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 74 | 41 | 0 | 2 | 3 | 3.30 | .272 | 1.10 | 7.5 | 2.5 | 9.8 | 43.2 | 36 | 17 | 16 | 4 | 12 | 47 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 2.93 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 34 | 0 | 1 | 1 | 4.54 | .292 | 1.24 | 7.8 | 3.5 | 10.4 | 39.2 | 34 | 22 | 20 | 9 | 15 | 45 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.85 |
| CL | Doolittle, S.Doolittle, Sean $ >> | 31 | 2018 | L | 98 | 54 | 0 | 3 | 10 | 3.55 | .300 | 1.22 | 8.7 | 2.3 | 8.4 | 58.1 | 56 | 23 | 23 | 10 | 15 | 54 | 0 | 19 | 4 | 0 | 0 | 4 | 0 | 4.36 |