| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 30 | 30 | 16 | 7 | 3.41 | .273 | 1.11 | 7.3 | 2.7 | 9.8 | 214.0 | 174 | 83 | 81 | 24 | 64 | 233 | 4 | 0 | 0 | 1 | 22 | 3 | 3 | 3.22 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 91 | 29 | 29 | 17 | 6 | 4.36 | .319 | 1.39 | 8.3 | 4.3 | 9.3 | 188.0 | 173 | 96 | 91 | 34 | 89 | 195 | 1 | 0 | 0 | 0 | 18 | 2 | 2 | 4.73 |
| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 78 | 29 | 29 | 11 | 6 | 4.62 | .303 | 1.26 | 8.3 | 3.1 | 5.6 | 177.1 | 163 | 93 | 91 | 21 | 60 | 110 | 1 | 0 | 0 | 1 | 14 | 8 | 2 | 4.45 |
| SP | Gooden, D.Gooden, Dwight # >> | 21 | 1985 | R | 75 | 29 | 29 | 11 | 15 | 4.75 | .302 | 1.28 | 8.8 | 2.8 | 6.4 | 200.2 | 195 | 114 | 106 | 27 | 62 | 143 | 8 | 0 | 0 | 1 | 10 | 4 | 2 | 4.32 |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 67 | 28 | 27 | 12 | 8 | 4.21 | .314 | 1.35 | 8.8 | 3.3 | 5.9 | 205.1 | 201 | 97 | 96 | 20 | 76 | 135 | 5 | 0 | 0 | 1 | 16 | 5 | 4 | 4.14 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 94 | 72 | 0 | 6 | 4 | 2.54 | .292 | 1.22 | 5.6 | 5.4 | 11.9 | 85.0 | 53 | 26 | 24 | 4 | 51 | 112 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 2.81 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 58 | 0 | 6 | 2 | 3.41 | .299 | 1.28 | 7.1 | 4.4 | 9.9 | 63.1 | 50 | 24 | 24 | 11 | 31 | 69 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 4.56 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 79 | 34 | 0 | 6 | 3 | 3.00 | .289 | 1.17 | 7.3 | 3.3 | 10.3 | 36.0 | 29 | 16 | 12 | 3 | 13 | 41 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.06 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 78 | 18 | 0 | 1 | 0 | 4.66 | .293 | 1.19 | 9.5 | 1.4 | 7.1 | 19.1 | 20 | 10 | 10 | 1 | 3 | 15 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 2.74 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 70 | 14 | 0 | 2 | 1 | 7.04 | .343 | 1.57 | 10.8 | 3.6 | 8.4 | 15.1 | 18 | 12 | 12 | 4 | 6 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.80 |
| CL | Eckersley, D.Eckersley, Dennis † $ >> | 36 | 1990 | R | 85 | 51 | 0 | 0 | 4 | 3.15 | .294 | 1.23 | 9.4 | 1.8 | 10.0 | 45.2 | 47 | 16 | 16 | 7 | 9 | 50 | 0 | 40 | 5 | 0 | 0 | 1 | 0 | 3.47 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 64 | 21 | 0 | 0 | 0 | 3.19 | .257 | 1.04 | 7.8 | 1.8 | 10.8 | 36.2 | 31 | 13 | 13 | 4 | 7 | 43 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.64 |