| SP | Martinez, P.Martinez, Pedro † # >> | 29 | 2000 | R | 100 | 19 | 19 | 12 | 6 | 3.26 | .265 | 1.05 | 7.3 | 2.2 | 9.2 | 143.2 | 116 | 55 | 52 | 17 | 35 | 146 | 4 | 0 | 0 | 1 | 12 | 4 | 1 | 3.32 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 84 | 18 | 18 | 6 | 6 | 6.29 | .370 | 1.73 | 11.2 | 4.4 | 8.3 | 93.0 | 116 | 71 | 65 | 17 | 45 | 86 | 0 | 0 | 0 | 0 | 7 | 3 | 1 | 5.08 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 71 | 18 | 18 | 6 | 10 | 6.16 | .370 | 1.71 | 11.1 | 4.3 | 6.6 | 102.1 | 126 | 74 | 70 | 18 | 49 | 75 | 0 | 0 | 0 | 0 | 6 | 5 | 3 | 5.41 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 17 | 17 | 8 | 5 | 3.38 | .320 | 1.40 | 7.3 | 5.4 | 9.1 | 104.0 | 84 | 39 | 39 | 6 | 62 | 105 | 0 | 0 | 0 | 0 | 8 | 1 | 1 | 3.55 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 17 | 17 | 9 | 5 | 4.86 | .335 | 1.49 | 9.8 | 3.6 | 7.1 | 113.0 | 123 | 62 | 61 | 23 | 45 | 89 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 5.35 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 49 | 0 | 1 | 0 | 4.36 | .281 | 1.14 | 7.6 | 2.7 | 9.1 | 64.0 | 54 | 32 | 31 | 9 | 19 | 65 | 0 | 8 | 1 | 0 | 0 | 2 | 3 | 3.78 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 85 | 44 | 0 | 3 | 0 | 4.27 | .298 | 1.24 | 8.8 | 2.3 | 8.7 | 59.0 | 58 | 28 | 28 | 7 | 15 | 57 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 3.47 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 38 | 0 | 1 | 4 | 6.05 | .370 | 1.76 | 9.2 | 6.9 | 11.4 | 38.2 | 39 | 26 | 26 | 4 | 29 | 48 | 0 | 5 | 1 | 0 | 0 | 0 | 5 | 4.13 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 53 | 25 | 0 | 0 | 2 | 5.04 | .289 | 1.22 | 8.4 | 2.7 | 9.0 | 30.1 | 28 | 17 | 17 | 2 | 9 | 30 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 2.77 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 51 | 7 | 0 | 0 | 1 | 14.73 | .421 | 2.18 | 18.0 | 2.6 | 2.6 | 7.1 | 14 | 12 | 12 | 4 | 2 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 10.71 |