| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 12 | 12 | 4 | 7 | 3.10 | .249 | 0.97 | 6.5 | 2.3 | 6.6 | 78.1 | 56 | 29 | 27 | 6 | 20 | 57 | 1 | 0 | 0 | 1 | 8 | 2 | 1 | 3.38 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 12 | 12 | 4 | 6 | 4.73 | .328 | 1.44 | 9.1 | 3.9 | 4.5 | 70.1 | 71 | 37 | 37 | 8 | 30 | 35 | 0 | 0 | 0 | 0 | 6 | 2 | 2 | 4.86 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 11 | 11 | 5 | 3 | 2.86 | .297 | 1.23 | 7.7 | 3.4 | 8.6 | 69.1 | 59 | 29 | 22 | 9 | 26 | 66 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 4.04 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 32 | 0 | 1 | 3 | 2.70 | .286 | 1.17 | 5.3 | 5.5 | 10.5 | 36.2 | 21 | 11 | 11 | 3 | 22 | 42 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 3.67 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 18 | 0 | 3 | 0 | 2.95 | .264 | 1.08 | 8.6 | 1.3 | 6.0 | 21.1 | 20 | 7 | 7 | 1 | 3 | 14 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 2.71 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 10 | 0 | 1 | 0 | 6.00 | .379 | 1.75 | 9.8 | 6.0 | 4.5 | 12.0 | 13 | 8 | 8 | 0 | 8 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.25 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 11 | 0 | 1 | 0 | 4.50 | .333 | 1.50 | 7.8 | 5.7 | 4.5 | 22.0 | 19 | 11 | 11 | 5 | 14 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 6.86 |