| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 19 | 19 | 9 | 7 | 4.15 | .296 | 1.24 | 8.3 | 3.0 | 7.0 | 112.2 | 103 | 55 | 52 | 16 | 37 | 87 | 1 | 0 | 0 | 0 | 12 | 2 | 1 | 4.35 |
| SP | Kluber, C.Kluber, Corey † # >> | 31 | 2017 | R | 89 | 18 | 18 | 10 | 2 | 2.73 | .262 | 1.03 | 7.7 | 1.7 | 6.7 | 128.2 | 109 | 45 | 39 | 11 | 24 | 95 | 3 | 0 | 0 | 1 | 12 | 4 | 2 | 3.29 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 18 | 18 | 6 | 8 | 5.38 | .337 | 1.50 | 10.4 | 3.0 | 8.2 | 107.0 | 124 | 69 | 64 | 18 | 36 | 98 | 2 | 0 | 0 | 0 | 8 | 3 | 1 | 4.45 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 17 | 17 | 3 | 9 | 6.54 | .347 | 1.57 | 10.8 | 3.4 | 5.1 | 85.1 | 102 | 65 | 62 | 20 | 32 | 48 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 6.13 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 17 | 17 | 6 | 5 | 4.62 | .326 | 1.42 | 9.6 | 3.1 | 5.9 | 113.0 | 121 | 63 | 58 | 9 | 39 | 74 | 4 | 0 | 0 | 0 | 8 | 4 | 5 | 3.87 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 44 | 0 | 3 | 3 | 1.63 | .216 | 0.83 | 5.5 | 2.0 | 10.7 | 49.2 | 30 | 10 | 9 | 3 | 11 | 58 | 0 | 21 | 1 | 0 | 0 | 0 | 0 | 2.10 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 49 | 0 | 3 | 0 | 2.81 | .287 | 1.19 | 6.2 | 4.6 | 8.1 | 51.1 | 35 | 21 | 16 | 6 | 26 | 46 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.31 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 52 | 0 | 4 | 3 | 6.53 | .338 | 1.50 | 10.2 | 3.5 | 8.0 | 60.2 | 68 | 48 | 44 | 13 | 23 | 53 | 0 | 0 | 3 | 0 | 0 | 2 | 4 | 5.30 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 34 | 0 | 4 | 1 | 3.60 | .322 | 1.40 | 8.8 | 3.8 | 9.4 | 45.0 | 44 | 21 | 18 | 4 | 19 | 47 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 3.40 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 36 | 0 | 2 | 1 | 6.02 | .332 | 1.47 | 9.6 | 3.7 | 9.2 | 46.1 | 49 | 31 | 31 | 15 | 19 | 47 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.50 |