| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 14 | 14 | 6 | 4 | 2.88 | .261 | 1.02 | 7.0 | 2.3 | 9.5 | 93.2 | 72 | 33 | 30 | 10 | 24 | 98 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 3.16 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 14 | 14 | 5 | 4 | 4.45 | .259 | 1.02 | 7.2 | 2.0 | 9.6 | 87.0 | 70 | 46 | 43 | 19 | 19 | 93 | 1 | 0 | 0 | 0 | 9 | 2 | 0 | 4.43 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 13 | 13 | 3 | 7 | 5.52 | .323 | 1.40 | 9.7 | 3.0 | 8.0 | 73.1 | 79 | 47 | 45 | 13 | 24 | 65 | 1 | 0 | 0 | 1 | 6 | 2 | 1 | 4.60 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 46 | 14 | 13 | 8 | 1 | 4.36 | .282 | 1.18 | 7.7 | 3.0 | 8.0 | 84.2 | 72 | 43 | 41 | 8 | 28 | 75 | 1 | 0 | 0 | 1 | 9 | 0 | 0 | 3.45 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 44 | 0 | 1 | 1 | 4.86 | .324 | 1.44 | 11.0 | 2.0 | 6.3 | 50.0 | 61 | 30 | 27 | 10 | 11 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.86 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 29 | 0 | 2 | 3 | 4.67 | .302 | 1.30 | 7.9 | 4.0 | 9.5 | 34.2 | 30 | 21 | 18 | 7 | 15 | 36 | 0 | 1 | 2 | 0 | 0 | 0 | 2 | 4.88 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 25 | 0 | 2 | 0 | 2.67 | .277 | 1.15 | 7.0 | 3.3 | 6.3 | 27.0 | 21 | 8 | 8 | 3 | 10 | 19 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4.15 |
| CL | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 31 | 0 | 2 | 3 | 3.58 | .310 | 1.29 | 5.9 | 5.9 | 9.0 | 32.2 | 21 | 14 | 13 | 4 | 21 | 32 | 0 | 15 | 2 | 0 | 0 | 2 | 2 | 4.78 |