| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 30 | 30 | 12 | 10 | 3.68 | .291 | 1.21 | 7.6 | 3.3 | 7.9 | 212.2 | 180 | 89 | 87 | 21 | 78 | 185 | 7 | 0 | 0 | 1 | 19 | 4 | 5 | 3.70 |
| SP | Maddux, G.Maddux, Greg † $ >> | 29 | 1995 | R | 89 | 30 | 30 | 14 | 11 | 3.10 | .265 | 1.06 | 7.7 | 1.9 | 5.4 | 243.2 | 207 | 89 | 84 | 23 | 51 | 146 | 13 | 0 | 0 | 1 | 21 | 6 | 3 | 3.73 |
| SP | Johnson, W.Johnson, Walter † >> | 26 | 1913 | R | 95 | 29 | 29 | 12 | 10 | 3.83 | .278 | 1.15 | 8.3 | 2.1 | 4.8 | 204.2 | 188 | 91 | 87 | 26 | 47 | 109 | 7 | 0 | 0 | 2 | 18 | 1 | 4 | 4.29 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 77 | 28 | 28 | 9 | 10 | 5.14 | .312 | 1.35 | 9.8 | 2.3 | 4.9 | 196.0 | 214 | 113 | 112 | 33 | 50 | 107 | 10 | 0 | 0 | 0 | 8 | 3 | 1 | 4.91 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 80 | 0 | 7 | 4 | 2.31 | .239 | 0.93 | 6.0 | 2.4 | 8.7 | 105.0 | 70 | 28 | 27 | 8 | 28 | 102 | 0 | 11 | 3 | 0 | 0 | 1 | 1 | 2.88 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 60 | 0 | 8 | 5 | 3.74 | .291 | 1.17 | 9.0 | 1.5 | 7.8 | 77.0 | 77 | 33 | 32 | 11 | 13 | 67 | 0 | 5 | 3 | 0 | 0 | 5 | 0 | 3.82 |
| RP | Miller, A.Miller, Andrew >> | 31 | 2016 | L | 92 | 38 | 0 | 4 | 5 | 4.20 | .274 | 1.09 | 7.2 | 2.6 | 10.2 | 45.0 | 36 | 21 | 21 | 8 | 13 | 51 | 0 | 5 | 4 | 0 | 0 | 2 | 0 | 4.04 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 85 | 27 | 0 | 2 | 2 | 2.56 | .208 | 0.79 | 5.8 | 1.5 | 9.6 | 31.2 | 20 | 9 | 9 | 3 | 5 | 33 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 2.61 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 19 | 0 | 0 | 1 | 4.91 | .340 | 1.50 | 9.4 | 4.1 | 5.3 | 22.0 | 23 | 12 | 12 | 4 | 10 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.68 |