| SP | Gonsolin, T.Gonsolin, Tony >> | 28 | 2022 | R | 98 | 30 | 30 | 15 | 6 | 3.39 | .299 | 1.26 | 7.6 | 3.7 | 6.6 | 151.1 | 128 | 59 | 57 | 18 | 62 | 111 | 0 | 0 | 0 | 0 | 11 | 4 | 1 | 4.39 |
| SP | Kershaw, C.Kershaw, Clayton >> | 34 | 2022 | L | 91 | 30 | 30 | 7 | 10 | 4.92 | .319 | 1.39 | 9.8 | 2.8 | 8.6 | 131.2 | 142 | 73 | 72 | 24 | 41 | 125 | 0 | 0 | 0 | 0 | 10 | 2 | 0 | 4.46 |
| RP | Dreifort, D.Dreifort, Darren >> | 25 | 1997 | R | 57 | 79 | 0 | 3 | 7 | 4.53 | .318 | 1.37 | 7.4 | 4.9 | 9.8 | 115.1 | 95 | 66 | 58 | 9 | 63 | 125 | 0 | 3 | 3 | 0 | 0 | 3 | 8 | 3.57 |
| RP | Heaney, A.Heaney, Andrew >> | 31 | 2022 | L | 62 | 48 | 0 | 5 | 2 | 3.29 | .266 | 1.06 | 6.7 | 2.9 | 10.8 | 82.0 | 61 | 33 | 30 | 13 | 26 | 98 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.70 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 34 | 2022 | R | 42 | 70 | 0 | 6 | 4 | 4.24 | .346 | 1.53 | 9.1 | 4.6 | 7.5 | 70.0 | 71 | 38 | 33 | 9 | 36 | 58 | 0 | 11 | 3 | 0 | 0 | 4 | 1 | 4.73 |
| RP | Osuna, A.Osuna, Antonio >> | 24 | 1997 | R | 73 | 44 | 0 | 1 | 4 | 4.03 | .293 | 1.23 | 7.7 | 3.5 | 8.1 | 60.1 | 51 | 28 | 27 | 6 | 23 | 54 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 3.70 |
| RP | Graterol, B.Graterol, Brusdar >> | 23 | 2022 | R | 74 | 69 | 0 | 4 | 4 | 4.29 | .286 | 1.16 | 8.4 | 2.1 | 6.7 | 92.1 | 86 | 48 | 44 | 19 | 21 | 68 | 0 | 6 | 2 | 0 | 0 | 4 | 0 | 5.02 |
| SP | Anderson, T.Anderson, Tyler >> | 32 | 2022 | L | 81 | 26 | 26 | 5 | 10 | 5.40 | .345 | 1.54 | 10.6 | 3.3 | 5.7 | 123.1 | 145 | 80 | 74 | 20 | 45 | 78 | 0 | 0 | 0 | 0 | 11 | 5 | 3 | 5.07 |
| SP | Park, C.Park, Chan Ho # >> | 24 | 1997 | R | 61 | 29 | 29 | 10 | 11 | 5.26 | .320 | 1.37 | 7.9 | 4.4 | 5.8 | 140.1 | 123 | 90 | 82 | 22 | 69 | 90 | 0 | 0 | 0 | 0 | 11 | 6 | 2 | 5.36 |
| SP | Valdez, I.Valdez, Ismael >> | 24 | 1997 | R | 59 | 8 | 0 | 0 | 0 | 5.79 | .317 | 1.39 | 9.0 | 4.0 | 6.0 | 9.1 | 9 | 7 | 6 | 0 | 4 | 6 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Buehler, W.Buehler, Walker # >> | 27 | 2022 | R | 32 | 45 | 0 | 3 | 3 | 8.17 | .404 | 1.98 | 14.3 | 3.7 | 7.2 | 82.2 | 130 | 84 | 75 | 21 | 34 | 66 | 0 | 2 | 3 | 0 | 0 | 4 | 3 | 6.11 |