| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 85 | 34 | 34 | 22 | 8 | 3.14 | .275 | 1.10 | 6.8 | 3.1 | 7.9 | 221.0 | 167 | 91 | 77 | 24 | 77 | 195 | 2 | 0 | 0 | 1 | 24 | 7 | 19 | 3.79 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 93 | 36 | 36 | 17 | 11 | 3.43 | .294 | 1.21 | 8.1 | 2.8 | 7.2 | 218.0 | 197 | 91 | 83 | 25 | 67 | 175 | 2 | 0 | 0 | 1 | 22 | 9 | 4 | 3.93 |
| SP | Lester, J.Lester, Jon # >> | 32 | 2016 | L | 89 | 35 | 35 | 11 | 14 | 4.14 | .303 | 1.27 | 8.5 | 2.9 | 8.8 | 208.2 | 197 | 105 | 96 | 20 | 67 | 203 | 0 | 0 | 0 | 0 | 20 | 8 | 0 | 3.38 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 80 | 33 | 33 | 11 | 8 | 5.13 | .326 | 1.43 | 9.5 | 3.3 | 7.8 | 186.0 | 197 | 117 | 106 | 39 | 69 | 162 | 0 | 0 | 0 | 0 | 15 | 4 | 10 | 5.16 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 108 | 0 | 8 | 5 | 3.95 | .292 | 1.21 | 6.6 | 4.3 | 10.3 | 109.1 | 80 | 50 | 48 | 15 | 52 | 125 | 0 | 2 | 3 | 0 | 0 | 3 | 9 | 4.01 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 61 | 66 | 0 | 1 | 4 | 3.42 | .271 | 1.10 | 7.6 | 2.3 | 9.8 | 71.0 | 60 | 28 | 27 | 12 | 18 | 77 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.83 |
| CL | Chapman, A.Chapman, Aroldis † >> | 28 | 2016 | L | 98 | 81 | 0 | 7 | 5 | 3.10 | .267 | 1.08 | 6.2 | 3.5 | 10.1 | 87.0 | 60 | 32 | 30 | 6 | 34 | 98 | 0 | 40 | 5 | 0 | 0 | 1 | 6 | 2.85 |
| SP | Hammel, J.Hammel, Jason # >> | 34 | 2016 | R | 41 | 33 | 31 | 8 | 9 | 6.53 | .347 | 1.57 | 10.5 | 3.6 | 6.8 | 153.0 | 178 | 118 | 111 | 35 | 62 | 115 | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 5.76 |