| SP | Johnson, R.Johnson, Randy >> | 38 | 2001 | L | 97 | 30 | 30 | 10 | 10 | 4.84 | .330 | 1.44 | 8.9 | 4.0 | 10.1 | 188.0 | 186 | 103 | 101 | 23 | 84 | 211 | 1 | 0 | 0 | 0 | 13 | 8 | 8 | 3.81 |
| SP | Halladay, R.Halladay, Roy † >> | 28 | 2005 | R | 87 | 30 | 30 | 13 | 10 | 3.37 | .273 | 1.11 | 8.4 | 1.6 | 7.1 | 213.2 | 199 | 87 | 80 | 31 | 39 | 168 | 5 | 0 | 0 | 2 | 18 | 3 | 6 | 3.91 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 29 | 29 | 8 | 14 | 5.75 | .332 | 1.45 | 10.3 | 2.8 | 7.4 | 164.1 | 188 | 112 | 105 | 27 | 51 | 135 | 0 | 0 | 0 | 0 | 13 | 6 | 2 | 4.54 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 28 | 28 | 9 | 14 | 5.14 | .308 | 1.29 | 8.8 | 2.9 | 5.9 | 161.0 | 157 | 96 | 92 | 30 | 51 | 106 | 1 | 0 | 0 | 1 | 13 | 7 | 4 | 5.19 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 29 | 26 | 10 | 6 | 3.99 | .301 | 1.27 | 8.9 | 2.4 | 5.7 | 169.0 | 168 | 77 | 75 | 26 | 46 | 107 | 3 | 0 | 0 | 1 | 15 | 4 | 2 | 4.62 |
| SU | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 91 | 78 | 0 | 3 | 4 | 3.61 | .289 | 1.18 | 7.4 | 3.3 | 8.8 | 84.2 | 69 | 34 | 34 | 5 | 31 | 82 | 0 | 5 | 6 | 0 | 0 | 3 | 0 | 3.04 |
| CL | Wagner, B.Wagner, Billy † $$ >> | 32 | 2003 | L | 90 | 63 | 0 | 6 | 6 | 3.13 | .276 | 1.13 | 6.8 | 3.4 | 8.7 | 69.0 | 52 | 24 | 24 | 10 | 26 | 67 | 0 | 33 | 2 | 0 | 0 | 1 | 2 | 4.12 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 73 | 82 | 0 | 11 | 3 | 4.33 | .325 | 1.38 | 8.8 | 3.6 | 7.1 | 89.1 | 87 | 43 | 43 | 12 | 36 | 70 | 0 | 1 | 2 | 0 | 0 | 6 | 3 | 4.60 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 69 | 0 | 2 | 1 | 4.43 | .330 | 1.43 | 7.8 | 5.0 | 7.7 | 61.0 | 53 | 30 | 30 | 9 | 34 | 52 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 5.03 |
| RP | Isringhausen, J.Isringhausen, Jason >> | 32 | 2004 | R | 40 | 58 | 0 | 2 | 1 | 3.80 | .318 | 1.39 | 8.5 | 4.1 | 7.8 | 66.1 | 62 | 29 | 28 | 10 | 30 | 57 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.65 |