| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 16 | 16 | 4 | 7 | 4.19 | .280 | 1.14 | 7.1 | 3.2 | 8.8 | 109.2 | 86 | 51 | 51 | 19 | 39 | 106 | 3 | 0 | 0 | 0 | 9 | 3 | 5 | 4.48 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 16 | 16 | 4 | 5 | 4.66 | .317 | 1.36 | 9.5 | 2.9 | 7.9 | 94.2 | 99 | 49 | 49 | 14 | 30 | 82 | 1 | 0 | 0 | 0 | 9 | 3 | 4 | 4.24 |
| SP | Buehrle, M.Buehrle, Mark # >> | 22 | 2001 | L | 66 | 16 | 16 | 6 | 6 | 5.11 | .316 | 1.33 | 9.6 | 2.3 | 6.8 | 100.1 | 107 | 58 | 57 | 13 | 26 | 75 | 0 | 0 | 0 | 0 | 6 | 6 | 1 | 4.15 |
| RP | Saito, T.Saito, Takashi # >> | 37 | 2007 | R | 100 | 41 | 0 | 2 | 3 | 4.68 | .282 | 1.13 | 8.4 | 1.9 | 6.2 | 57.2 | 53 | 30 | 30 | 11 | 12 | 39 | 0 | 0 | 4 | 0 | 0 | 3 | 0 | 4.93 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 86 | 41 | 0 | 4 | 1 | 1.73 | .250 | 1.00 | 6.9 | 2.1 | 8.3 | 52.0 | 40 | 10 | 10 | 2 | 12 | 48 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.35 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 90 | 32 | 0 | 3 | 2 | 2.58 | .299 | 1.25 | 6.2 | 5.2 | 8.5 | 38.1 | 26 | 11 | 11 | 1 | 22 | 36 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 3.26 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 16 | 0 | 2 | 0 | 1.74 | .262 | 1.06 | 8.1 | 1.8 | 8.6 | 20.2 | 18 | 4 | 4 | 1 | 4 | 19 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.35 |
| RP | Politte, C.Politte, Cliff >> | 31 | 2005 | R | 65 | 14 | 0 | 0 | 0 | 2.00 | .260 | 1.06 | 5.5 | 4.0 | 7.5 | 18.0 | 11 | 4 | 4 | 1 | 8 | 15 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.39 |
| CL | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 28 | 0 | 1 | 2 | 2.70 | .250 | 0.93 | 3.9 | 4.5 | 7.8 | 30.0 | 13 | 10 | 9 | 1 | 15 | 26 | 0 | 15 | 2 | 0 | 0 | 2 | 5 | 3.40 |