| SP | Santana, J.Santana, Johan † # >> | 25 | 2004 | L | 100 | 30 | 30 | 21 | 4 | 2.81 | .248 | 0.98 | 6.7 | 2.1 | 9.1 | 214.2 | 160 | 68 | 67 | 18 | 51 | 216 | 1 | 0 | 0 | 1 | 22 | 1 | 1 | 2.80 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 29 | 29 | 10 | 7 | 5.08 | .328 | 1.46 | 8.7 | 4.5 | 7.5 | 159.1 | 153 | 93 | 90 | 23 | 79 | 133 | 1 | 0 | 0 | 1 | 11 | 1 | 4 | 4.72 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 79 | 29 | 29 | 10 | 11 | 7.26 | .374 | 1.74 | 12.6 | 3.1 | 5.7 | 148.2 | 208 | 125 | 120 | 40 | 51 | 94 | 0 | 0 | 0 | 0 | 4 | 7 | 3 | 6.42 |
| CL | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 64 | 0 | 3 | 3 | 4.45 | .287 | 1.18 | 8.1 | 2.6 | 9.9 | 58.2 | 52 | 31 | 29 | 10 | 17 | 64 | 0 | 40 | 3 | 0 | 0 | 2 | 1 | 4.02 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 77 | 0 | 3 | 8 | 4.25 | .330 | 1.44 | 10.7 | 2.3 | 9.4 | 95.1 | 113 | 46 | 45 | 14 | 24 | 99 | 0 | 2 | 2 | 0 | 0 | 4 | 0 | 3.72 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 71 | 0 | 3 | 8 | 5.79 | .369 | 1.67 | 11.1 | 3.9 | 9.2 | 73.0 | 90 | 47 | 47 | 13 | 32 | 75 | 0 | 0 | 5 | 0 | 0 | 6 | 1 | 4.82 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 75 | 61 | 0 | 5 | 1 | 4.85 | .350 | 1.57 | 10.8 | 3.3 | 9.4 | 65.0 | 78 | 37 | 35 | 8 | 24 | 68 | 0 | 2 | 3 | 0 | 0 | 3 | 7 | 3.75 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 50 | 0 | 3 | 1 | 3.91 | .312 | 1.34 | 7.0 | 5.1 | 10.5 | 53.0 | 41 | 24 | 23 | 7 | 30 | 62 | 0 | 0 | 3 | 0 | 0 | 1 | 4 | 4.13 |