| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 34 | 34 | 13 | 15 | 4.32 | .300 | 1.28 | 8.4 | 3.2 | 8.5 | 220.2 | 205 | 118 | 106 | 27 | 77 | 207 | 4 | 0 | 0 | 1 | 16 | 2 | 3 | 3.79 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 32 | 32 | 13 | 14 | 4.37 | .308 | 1.31 | 9.2 | 2.6 | 7.8 | 222.2 | 227 | 115 | 108 | 28 | 64 | 193 | 3 | 0 | 0 | 1 | 19 | 6 | 4 | 3.85 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 31 | 31 | 12 | 17 | 5.43 | .349 | 1.58 | 11.1 | 3.2 | 5.4 | 213.2 | 262 | 136 | 129 | 22 | 76 | 128 | 8 | 0 | 0 | 2 | 10 | 6 | 3 | 4.30 |
| RP | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 86 | 0 | 4 | 4 | 3.56 | .305 | 1.29 | 7.5 | 4.2 | 9.5 | 118.2 | 98 | 50 | 47 | 11 | 55 | 124 | 0 | 16 | 3 | 0 | 0 | 3 | 4 | 3.58 |
| RP | Gossage, R.Gossage, Rich # >> | 30 | 1981 | R | 90 | 74 | 0 | 3 | 7 | 4.91 | .291 | 1.21 | 7.7 | 3.2 | 9.1 | 99.0 | 85 | 54 | 54 | 12 | 35 | 100 | 0 | 8 | 0 | 0 | 0 | 2 | 4 | 3.68 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 52 | 0 | 3 | 3 | 5.05 | .293 | 1.23 | 8.6 | 2.6 | 4.4 | 67.2 | 64 | 38 | 38 | 20 | 19 | 33 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 6.79 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 50 | 0 | 2 | 3 | 4.91 | .327 | 1.44 | 9.2 | 3.8 | 9.7 | 55.0 | 56 | 31 | 30 | 12 | 23 | 59 | 0 | 8 | 2 | 0 | 0 | 1 | 6 | 5.00 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 34 | 0 | 2 | 2 | 3.06 | .312 | 1.33 | 9.8 | 2.3 | 10.0 | 35.1 | 38 | 12 | 12 | 1 | 9 | 39 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 2.00 |