| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 35 | 35 | 12 | 17 | 4.31 | .303 | 1.29 | 8.8 | 2.8 | 5.3 | 250.1 | 244 | 127 | 120 | 38 | 78 | 148 | 7 | 0 | 0 | 1 | 18 | 5 | 4 | 4.79 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 34 | 34 | 12 | 16 | 3.96 | .277 | 1.14 | 7.7 | 2.6 | 5.6 | 243.1 | 207 | 116 | 107 | 29 | 71 | 150 | 6 | 0 | 0 | 0 | 20 | 2 | 3 | 4.22 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 33 | 33 | 8 | 9 | 4.67 | .320 | 1.38 | 9.6 | 2.9 | 5.3 | 167.2 | 179 | 98 | 87 | 23 | 53 | 99 | 0 | 0 | 0 | 0 | 9 | 5 | 4 | 4.65 |
| SP | White, D.White, Doc † # >> | 27 | 1906 | L | 71 | 33 | 33 | 13 | 12 | 3.74 | .299 | 1.26 | 8.8 | 2.5 | 3.9 | 231.0 | 227 | 116 | 96 | 22 | 65 | 100 | 5 | 0 | 0 | 3 | 22 | 3 | 3 | 4.26 |
| SP | Waddell, R.Waddell, Rube # >> | 29 | 1905 | L | 67 | 31 | 31 | 11 | 11 | 5.13 | .323 | 1.41 | 9.6 | 3.1 | 5.4 | 200.0 | 214 | 120 | 114 | 24 | 68 | 121 | 3 | 0 | 0 | 1 | 12 | 4 | 3 | 4.43 |
| RP | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 95 | 0 | 9 | 5 | 4.03 | .284 | 1.19 | 8.1 | 2.7 | 8.6 | 111.2 | 100 | 54 | 50 | 10 | 33 | 106 | 0 | 14 | 5 | 0 | 0 | 0 | 3 | 3.15 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 65 | 0 | 1 | 6 | 2.80 | .302 | 1.27 | 6.0 | 5.5 | 10.3 | 74.0 | 49 | 28 | 23 | 3 | 45 | 85 | 0 | 5 | 3 | 0 | 0 | 2 | 6 | 3.14 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 41 | 0 | 4 | 4 | 4.62 | .324 | 1.38 | 8.8 | 3.7 | 10.6 | 39.0 | 38 | 22 | 20 | 5 | 16 | 46 | 0 | 5 | 2 | 0 | 0 | 2 | 2 | 3.69 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 29 | 0 | 0 | 2 | 6.98 | .321 | 1.35 | 8.7 | 3.7 | 7.8 | 29.2 | 28 | 25 | 23 | 7 | 12 | 25 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 5.86 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 10 | 0 | 1 | 1 | 3.75 | .301 | 1.21 | 8.3 | 2.6 | 6.4 | 24.0 | 22 | 11 | 10 | 2 | 7 | 17 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 3.79 |