| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 37 | 37 | 14 | 14 | 3.27 | .268 | 1.10 | 7.5 | 2.3 | 7.9 | 272.2 | 228 | 100 | 99 | 30 | 71 | 238 | 3 | 0 | 0 | 0 | 24 | 1 | 8 | 3.48 |
| SP | Arrieta, J.Arrieta, Jake † >> | 29 | 2015 | R | 93 | 36 | 36 | 18 | 11 | 3.21 | .269 | 1.08 | 7.1 | 2.6 | 7.6 | 255.0 | 201 | 94 | 91 | 26 | 74 | 214 | 8 | 0 | 0 | 4 | 25 | 7 | 6 | 3.60 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 35 | 35 | 17 | 12 | 4.36 | .313 | 1.33 | 8.5 | 3.5 | 8.0 | 208.1 | 197 | 108 | 101 | 29 | 81 | 185 | 0 | 0 | 0 | 0 | 18 | 7 | 2 | 4.30 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 33 | 33 | 10 | 7 | 5.30 | .344 | 1.54 | 10.7 | 3.2 | 5.0 | 168.0 | 200 | 109 | 99 | 24 | 59 | 93 | 0 | 0 | 0 | 0 | 9 | 5 | 4 | 4.89 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 76 | 31 | 31 | 16 | 7 | 3.87 | .280 | 1.14 | 8.3 | 2.0 | 5.2 | 244.0 | 224 | 110 | 105 | 34 | 54 | 140 | 12 | 0 | 0 | 1 | 14 | 7 | 5 | 4.41 |
| RP | Gossage, R.Gossage, Rich † >> | 30 | 1981 | R | 90 | 80 | 0 | 6 | 3 | 1.72 | .271 | 1.08 | 6.5 | 3.4 | 7.7 | 99.2 | 71 | 24 | 19 | 5 | 37 | 85 | 0 | 12 | 3 | 0 | 0 | 3 | 2 | 3.15 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 51 | 0 | 6 | 5 | 3.05 | .280 | 1.17 | 5.6 | 4.9 | 9.2 | 59.0 | 37 | 23 | 20 | 6 | 32 | 60 | 0 | 5 | 3 | 0 | 0 | 0 | 2 | 3.92 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 42 | 0 | 2 | 4 | 2.65 | .257 | 1.00 | 5.5 | 3.5 | 11.8 | 51.0 | 31 | 16 | 15 | 4 | 20 | 67 | 0 | 9 | 3 | 0 | 0 | 2 | 5 | 2.69 |
| RP | Gregerson, L.Gregerson, Luke # >> | 26 | 2010 | R | 73 | 30 | 0 | 4 | 4 | 4.84 | .279 | 1.16 | 9.0 | 1.5 | 9.3 | 35.1 | 35 | 20 | 19 | 7 | 6 | 36 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.06 |