| SP | Koufax, S.Koufax, Sandy † $ >> | 30 | 1965 | L | 97 | 24 | 24 | 11 | 9 | 4.07 | .287 | 1.18 | 7.9 | 2.7 | 8.6 | 172.2 | 151 | 82 | 78 | 18 | 52 | 165 | 8 | 0 | 0 | 1 | 11 | 5 | 9 | 3.44 |
| SP | Greinke, Z.Greinke, Zack $ >> | 32 | 2015 | R | 94 | 23 | 23 | 12 | 6 | 3.26 | .308 | 1.32 | 9.7 | 2.2 | 5.6 | 160.1 | 173 | 65 | 58 | 14 | 39 | 100 | 2 | 0 | 0 | 0 | 16 | 2 | 2 | 3.66 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 23 | 23 | 10 | 7 | 4.00 | .308 | 1.31 | 6.9 | 4.9 | 9.7 | 148.1 | 114 | 71 | 66 | 17 | 81 | 159 | 2 | 0 | 0 | 1 | 12 | 3 | 2 | 4.05 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 23 | 23 | 6 | 10 | 4.32 | .272 | 1.11 | 8.1 | 1.9 | 6.8 | 162.1 | 146 | 85 | 78 | 26 | 34 | 123 | 4 | 0 | 0 | 1 | 12 | 2 | 1 | 4.23 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 21 | 21 | 11 | 5 | 5.18 | .322 | 1.41 | 9.8 | 2.9 | 6.4 | 147.2 | 160 | 92 | 85 | 24 | 48 | 105 | 6 | 0 | 0 | 0 | 6 | 2 | 1 | 4.71 |
| RP | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 58 | 0 | 5 | 1 | 2.52 | .272 | 1.08 | 6.1 | 3.7 | 9.8 | 71.1 | 48 | 20 | 20 | 4 | 29 | 77 | 0 | 8 | 1 | 0 | 0 | 3 | 0 | 2.92 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 41 | 0 | 4 | 2 | 3.49 | .286 | 1.16 | 5.3 | 5.1 | 11.6 | 49.0 | 29 | 20 | 19 | 2 | 28 | 63 | 0 | 7 | 0 | 0 | 0 | 2 | 0 | 2.80 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 32 | 0 | 4 | 2 | 5.70 | .359 | 1.60 | 12.8 | 1.8 | 7.0 | 36.1 | 51 | 25 | 23 | 8 | 7 | 28 | 0 | 3 | 3 | 0 | 0 | 3 | 0 | 5.17 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 21 | 0 | 2 | 2 | 3.60 | .292 | 1.20 | 9.0 | 1.8 | 6.1 | 25.0 | 25 | 10 | 10 | 3 | 5 | 17 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 3.92 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 11 | 0 | 1 | 4 | 4.38 | .315 | 1.38 | 9.8 | 3.0 | 11.3 | 12.1 | 13 | 6 | 6 | 2 | 4 | 15 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.67 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 9 | 0 | 0 | 0 | 2.89 | .364 | 1.71 | 12.0 | 4.0 | 8.0 | 9.1 | 12 | 3 | 3 | 0 | 4 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.56 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 17 | 0 | 0 | 0 | 2.76 | .248 | 0.99 | 5.6 | 3.4 | 10.6 | 29.1 | 18 | 9 | 9 | 6 | 11 | 34 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.48 |