| SP | deGrom, J.deGrom, Jacob $ >> | 33 | 2021 | R | 100 | 30 | 30 | 15 | 10 | 3.38 | .252 | 1.00 | 7.3 | 1.7 | 8.8 | 205.0 | 166 | 79 | 77 | 29 | 39 | 200 | 1 | 0 | 0 | 1 | 18 | 2 | 0 | 3.49 |
| SP | Alexander, P.Alexander, Pete $ >> | 28 | 1915 | R | 88 | 27 | 27 | 14 | 9 | 4.15 | .282 | 1.16 | 8.1 | 2.3 | 4.6 | 197.1 | 178 | 94 | 91 | 24 | 51 | 101 | 7 | 0 | 0 | 1 | 13 | 4 | 5 | 4.40 |
| SP | Maddux, G.Maddux, Greg † # >> | 29 | 1995 | R | 89 | 29 | 29 | 17 | 7 | 3.64 | .275 | 1.12 | 8.4 | 1.8 | 5.1 | 215.1 | 200 | 93 | 87 | 25 | 42 | 123 | 9 | 0 | 0 | 5 | 15 | 3 | 2 | 4.00 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 28 | 28 | 12 | 10 | 4.67 | .295 | 1.22 | 8.8 | 2.1 | 5.0 | 206.0 | 202 | 108 | 107 | 27 | 49 | 115 | 12 | 0 | 0 | 0 | 12 | 7 | 2 | 4.40 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 75 | 0 | 3 | 2 | 3.67 | .281 | 1.12 | 6.5 | 3.6 | 9.3 | 95.2 | 69 | 40 | 39 | 13 | 38 | 98 | 0 | 10 | 3 | 0 | 0 | 5 | 8 | 4.07 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 51 | 0 | 5 | 5 | 2.13 | .259 | 1.03 | 5.9 | 3.5 | 7.7 | 67.2 | 44 | 16 | 16 | 6 | 26 | 57 | 0 | 5 | 0 | 0 | 0 | 1 | 0 | 3.67 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 40 | 0 | 4 | 3 | 2.61 | .264 | 1.06 | 5.1 | 4.5 | 9.2 | 48.1 | 27 | 14 | 14 | 2 | 24 | 49 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.06 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 30 | 0 | 1 | 3 | 3.62 | .287 | 1.21 | 7.9 | 3.1 | 7.6 | 32.1 | 28 | 14 | 13 | 4 | 11 | 27 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 3.97 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 26 | 0 | 1 | 1 | 2.97 | .305 | 1.32 | 7.8 | 4.2 | 7.8 | 30.1 | 26 | 10 | 10 | 3 | 14 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.97 |