| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 100 | 11 | 11 | 5 | 5 | 3.80 | .231 | 0.89 | 6.6 | 1.4 | 10.8 | 71.0 | 52 | 30 | 30 | 9 | 11 | 85 | 1 | 0 | 0 | 1 | 7 | 1 | 0 | 2.76 |
| SP | Perez, E.Perez, Eury # >> | 22 | 2025 | R | 89 | 11 | 11 | 1 | 4 | 4.76 | .354 | 1.63 | 9.9 | 4.8 | 10.6 | 51.0 | 56 | 29 | 27 | 5 | 27 | 60 | 0 | 0 | 0 | 0 | 0 | 1 | 8 | 3.57 |
| SP | Nelson, R.Nelson, Ryne >> | 27 | 2025 | R | 79 | 11 | 11 | 4 | 1 | 3.53 | .285 | 1.16 | 7.9 | 2.6 | 7.8 | 58.2 | 51 | 23 | 23 | 4 | 17 | 50 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 3.16 |
| RP | Morejon, A.Morejon, Adrian >> | 26 | 2025 | L | 87 | 32 | 0 | 0 | 0 | 4.55 | .288 | 1.21 | 9.0 | 2.2 | 7.1 | 29.2 | 29 | 15 | 15 | 3 | 7 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 3.48 |
| RP | Bazardo, E.Bazardo, Eduard >> | 29 | 2025 | R | 83 | 35 | 0 | 2 | 1 | 2.59 | .309 | 1.34 | 7.5 | 4.6 | 7.5 | 31.1 | 26 | 9 | 9 | 2 | 16 | 26 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.71 |
| RP | Bednar, D.Bednar, David >> | 30 | 2025 | R | 77 | 26 | 0 | 3 | 2 | 4.71 | .315 | 1.38 | 8.1 | 4.3 | 9.0 | 21.0 | 19 | 11 | 11 | 3 | 10 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.29 |
| RP | Pomeranz, D.Pomeranz, Drew >> | 36 | 2025 | L | 70 | 29 | 0 | 4 | 0 | 4.29 | .308 | 1.33 | 9.4 | 2.6 | 8.6 | 21.0 | 22 | 10 | 10 | 1 | 6 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.57 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 67 | 21 | 0 | 1 | 0 | 5.23 | .361 | 1.50 | 10.4 | 3.6 | 8.1 | 20.2 | 23 | 12 | 12 | 1 | 8 | 18 | 0 | 0 | 0 | 0 | 0 | 4 | 0 | 3.65 |
| SU | Keller, B.Keller, Brad >> | 29 | 2025 | R | 87 | 16 | 0 | 0 | 0 | 1.13 | .294 | 1.25 | 7.3 | 3.9 | 10.1 | 16.0 | 13 | 2 | 2 | 0 | 7 | 18 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.06 |
| SP | Littell, Z.Littell, Zack >> | 29 | 2025 | R | 60 | 14 | 0 | 4 | 2 | 7.02 | .390 | 1.92 | 13.4 | 4.1 | 7.1 | 33.1 | 49 | 30 | 26 | 8 | 15 | 26 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.94 |