| SP | Hardin, J.Hardin, Jim † >> | 25 | 1968 | R | 97 | 27 | 27 | 15 | 7 | 3.81 | .301 | 1.27 | 8.5 | 3.0 | 5.5 | 193.2 | 182 | 86 | 82 | 14 | 64 | 118 | 5 | 0 | 0 | 0 | 18 | 4 | 5 | 3.78 |
| SP | Mathewson, C.Mathewson, Christy † >> | 33 | 1913 | R | 84 | 27 | 27 | 16 | 7 | 3.25 | .288 | 1.20 | 8.7 | 2.1 | 4.4 | 216.0 | 209 | 89 | 78 | 12 | 50 | 105 | 9 | 0 | 0 | 1 | 17 | 3 | 7 | 3.49 |
| SP | Scherzer, M.Scherzer, Max >> | 26 | 2010 | R | 82 | 26 | 26 | 12 | 7 | 4.55 | .307 | 1.32 | 8.7 | 3.3 | 5.5 | 160.1 | 154 | 91 | 81 | 5 | 58 | 98 | 2 | 0 | 0 | 1 | 14 | 1 | 6 | 3.29 |
| SP | Pettitte, A.Pettitte, Andy >> | 38 | 2010 | L | 71 | 26 | 26 | 8 | 9 | 6.23 | .372 | 1.76 | 12.4 | 3.5 | 5.9 | 141.2 | 195 | 112 | 98 | 14 | 55 | 92 | 0 | 0 | 0 | 0 | 8 | 2 | 4 | 4.20 |
| SP | Maddux, G.Maddux, Greg # >> | 42 | 2008 | R | 64 | 25 | 25 | 4 | 9 | 5.96 | .352 | 1.62 | 11.7 | 2.9 | 4.5 | 137.1 | 178 | 101 | 91 | 17 | 44 | 69 | 0 | 0 | 0 | 0 | 7 | 2 | 3 | 4.61 |
| RP | Bailey, A.Bailey, Andrew >> | 26 | 2010 | R | 98 | 67 | 0 | 6 | 3 | 3.09 | .271 | 1.09 | 6.7 | 3.2 | 4.6 | 93.1 | 69 | 33 | 32 | 6 | 33 | 48 | 0 | 8 | 3 | 0 | 0 | 2 | 0 | 3.94 |
| RP | Donnelly, B.Donnelly, Brendan † >> | 33 | 2004 | R | 87 | 63 | 0 | 7 | 4 | 3.04 | .304 | 1.27 | 7.4 | 4.1 | 9.6 | 77.0 | 63 | 29 | 26 | 8 | 35 | 82 | 0 | 11 | 3 | 0 | 0 | 3 | 0 | 3.70 |
| RP | Barojas, S.Barojas, Salome >> | 26 | 1983 | R | 74 | 49 | 0 | 1 | 4 | 4.01 | .327 | 1.46 | 8.6 | 4.6 | 4.3 | 67.1 | 64 | 30 | 30 | 3 | 34 | 32 | 0 | 3 | 2 | 0 | 0 | 0 | 2 | 4.15 |
| RP | Guerrier, M.Guerrier, Matt >> | 33 | 2011 | R | 61 | 39 | 0 | 2 | 3 | 4.68 | .317 | 1.39 | 8.6 | 4.1 | 5.4 | 42.1 | 40 | 24 | 22 | 4 | 19 | 25 | 0 | 3 | 2 | 0 | 0 | 0 | 1 | 4.40 |
| RP | Jeffress, J.Jeffress, Jeremy >> | 28 | 2016 | R | 52 | 34 | 0 | 3 | 1 | 5.97 | .354 | 1.64 | 10.9 | 4.2 | 6.1 | 34.2 | 41 | 23 | 23 | 5 | 16 | 23 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.97 |
| SP | Derringer, P.Derringer, Paul >> | 37 | 1943 | R | 46 | 13 | 0 | 1 | 2 | 5.93 | .406 | 1.98 | 15.9 | 2.8 | 4.8 | 13.2 | 23 | 9 | 9 | 1 | 4 | 7 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.08 |