| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 16 | 16 | 10 | 2 | 3.02 | .269 | 1.09 | 6.1 | 3.7 | 7.8 | 113.1 | 77 | 38 | 38 | 11 | 46 | 98 | 0 | 0 | 0 | 0 | 12 | 2 | 2 | 3.81 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 16 | 16 | 5 | 4 | 4.49 | .294 | 1.24 | 8.9 | 2.3 | 8.9 | 106.1 | 105 | 53 | 53 | 16 | 27 | 105 | 0 | 0 | 0 | 0 | 8 | 1 | 5 | 3.77 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 14 | 14 | 9 | 3 | 2.50 | .274 | 1.10 | 7.9 | 2.1 | 6.1 | 100.2 | 88 | 30 | 28 | 4 | 23 | 68 | 0 | 0 | 0 | 0 | 11 | 3 | 2 | 2.94 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 15 | 14 | 5 | 3 | 3.53 | .275 | 1.13 | 7.8 | 2.4 | 4.2 | 102.0 | 88 | 47 | 40 | 14 | 27 | 48 | 0 | 0 | 0 | 0 | 8 | 1 | 1 | 4.67 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 51 | 0 | 5 | 0 | 3.94 | .301 | 1.27 | 7.0 | 4.6 | 11.0 | 45.2 | 35 | 20 | 20 | 5 | 23 | 55 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.60 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 41 | 0 | 2 | 1 | 2.67 | .252 | 0.95 | 7.6 | 1.1 | 10.1 | 33.2 | 28 | 10 | 10 | 1 | 4 | 37 | 0 | 6 | 1 | 0 | 0 | 2 | 0 | 1.70 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 27 | 0 | 0 | 0 | 0.96 | .200 | 0.70 | 3.0 | 3.5 | 10.5 | 18.2 | 6 | 2 | 2 | 1 | 7 | 21 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 2.72 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 37 | 0 | 3 | 0 | 1.73 | .243 | 0.96 | 5.9 | 2.8 | 9.7 | 26.0 | 17 | 5 | 5 | 2 | 8 | 28 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 2.77 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 64 | 9 | 3 | 3 | 3 | 5.30 | .321 | 1.37 | 10.0 | 2.4 | 5.8 | 37.1 | 41 | 23 | 22 | 7 | 10 | 24 | 0 | 0 | 1 | 0 | 1 | 2 | 0 | 5.14 |