| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 16 | 16 | 6 | 4 | 4.35 | .327 | 1.45 | 8.5 | 4.5 | 8.3 | 99.1 | 94 | 49 | 48 | 10 | 50 | 91 | 0 | 0 | 0 | 0 | 6 | 1 | 3 | 4.02 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 16 | 16 | 5 | 4 | 4.39 | .303 | 1.30 | 8.9 | 2.8 | 6.1 | 108.2 | 107 | 54 | 53 | 11 | 34 | 73 | 4 | 0 | 0 | 0 | 8 | 1 | 3 | 3.94 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 16 | 16 | 4 | 5 | 3.71 | .321 | 1.40 | 8.3 | 4.3 | 5.2 | 104.1 | 96 | 52 | 43 | 12 | 50 | 60 | 2 | 0 | 0 | 0 | 10 | 2 | 0 | 4.85 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 15 | 15 | 5 | 7 | 5.54 | .325 | 1.43 | 8.0 | 5.0 | 8.0 | 79.2 | 70 | 51 | 49 | 9 | 44 | 70 | 0 | 0 | 0 | 0 | 7 | 1 | 0 | 4.42 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 86 | 46 | 0 | 2 | 2 | 3.82 | .264 | 1.08 | 7.7 | 2.1 | 10.8 | 35.1 | 30 | 15 | 15 | 8 | 8 | 42 | 0 | 4 | 4 | 0 | 0 | 0 | 2 | 4.26 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 54 | 0 | 2 | 2 | 1.85 | .190 | 0.71 | 4.8 | 1.6 | 7.4 | 34.0 | 18 | 7 | 7 | 2 | 6 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.65 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 36 | 0 | 3 | 2 | 2.06 | .276 | 1.11 | 5.4 | 4.6 | 7.7 | 35.0 | 21 | 8 | 8 | 0 | 18 | 30 | 0 | 6 | 0 | 0 | 0 | 1 | 1 | 2.91 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 43 | 13 | 0 | 2 | 2 | 2.78 | .320 | 1.41 | 7.4 | 5.7 | 3.7 | 22.2 | 18 | 7 | 7 | 0 | 14 | 9 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.09 |