| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 32 | 32 | 9 | 15 | 3.59 | .289 | 1.18 | 7.6 | 3.1 | 4.6 | 241.0 | 203 | 107 | 96 | 27 | 82 | 123 | 5 | 0 | 0 | 1 | 20 | 9 | 3 | 4.57 |
| SP | White, D.White, Doc † # >> | 27 | 1906 | L | 71 | 32 | 32 | 13 | 16 | 3.91 | .311 | 1.32 | 9.4 | 2.6 | 4.4 | 225.2 | 234 | 108 | 98 | 18 | 64 | 109 | 5 | 0 | 0 | 1 | 15 | 8 | 4 | 4.03 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 29 | 29 | 7 | 13 | 4.99 | .331 | 1.46 | 10.6 | 2.6 | 3.9 | 212.2 | 249 | 125 | 118 | 26 | 61 | 93 | 6 | 0 | 0 | 1 | 11 | 5 | 3 | 4.65 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 30 | 29 | 10 | 9 | 4.68 | .335 | 1.50 | 9.2 | 4.3 | 5.0 | 177.0 | 181 | 94 | 92 | 11 | 84 | 98 | 0 | 0 | 0 | 0 | 17 | 3 | 4 | 4.18 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 95 | 84 | 0 | 5 | 5 | 3.20 | .320 | 1.40 | 7.5 | 5.1 | 7.4 | 107.0 | 89 | 42 | 38 | 7 | 61 | 88 | 0 | 6 | 5 | 0 | 0 | 1 | 2 | 3.94 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 65 | 0 | 7 | 3 | 2.96 | .297 | 1.25 | 7.2 | 4.1 | 8.8 | 79.0 | 63 | 34 | 26 | 6 | 36 | 77 | 0 | 7 | 2 | 0 | 0 | 1 | 7 | 3.44 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 18 | 1 | 1 | 4 | 6.39 | .336 | 1.48 | 10.5 | 2.9 | 7.0 | 31.0 | 36 | 25 | 22 | 5 | 10 | 24 | 0 | 4 | 1 | 0 | 0 | 1 | 1 | 4.61 |