| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 22 | 22 | 10 | 9 | 3.55 | .285 | 1.16 | 7.5 | 2.9 | 7.5 | 165.0 | 137 | 66 | 65 | 20 | 54 | 138 | 3 | 0 | 0 | 1 | 12 | 6 | 0 | 3.99 |
| SP | Alexander, P.Alexander, Pete # >> | 28 | 1915 | R | 88 | 21 | 21 | 7 | 10 | 4.50 | .296 | 1.23 | 9.0 | 2.1 | 5.7 | 158.0 | 158 | 86 | 79 | 17 | 37 | 100 | 6 | 0 | 0 | 0 | 11 | 4 | 2 | 3.91 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 21 | 21 | 7 | 8 | 4.86 | .310 | 1.33 | 9.1 | 2.9 | 8.0 | 126.0 | 127 | 68 | 68 | 16 | 40 | 112 | 1 | 0 | 0 | 0 | 9 | 3 | 4 | 3.90 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 76 | 21 | 21 | 10 | 10 | 5.24 | .334 | 1.46 | 10.5 | 2.7 | 5.1 | 156.1 | 182 | 96 | 91 | 25 | 46 | 89 | 11 | 0 | 0 | 0 | 5 | 7 | 2 | 4.96 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 21 | 21 | 6 | 9 | 4.94 | .339 | 1.53 | 9.9 | 3.9 | 4.5 | 142.0 | 156 | 83 | 78 | 25 | 61 | 71 | 1 | 0 | 0 | 0 | 10 | 1 | 2 | 5.60 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 56 | 0 | 4 | 2 | 3.63 | .318 | 1.36 | 7.7 | 4.6 | 8.6 | 69.1 | 59 | 30 | 28 | 6 | 35 | 66 | 0 | 8 | 2 | 0 | 0 | 3 | 0 | 3.87 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 35 | 0 | 5 | 0 | 3.89 | .288 | 1.22 | 8.3 | 2.7 | 6.8 | 37.0 | 34 | 17 | 16 | 6 | 11 | 28 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 4.49 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 17 | 0 | 0 | 1 | 4.64 | .340 | 1.45 | 9.4 | 3.9 | 8.1 | 21.1 | 22 | 11 | 11 | 3 | 9 | 19 | 0 | 3 | 0 | 0 | 0 | 2 | 1 | 4.62 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 1 | 0 | 0 | 0 | 0.00 | .111 | 0.38 | 0.0 | 4.5 | 4.5 | 2.2 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.50 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 59 | 16 | 0 | 2 | 2 | 3.00 | .357 | 1.67 | 9.4 | 5.6 | 7.9 | 24.0 | 25 | 9 | 8 | 4 | 15 | 21 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 5.29 |