| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 7 | 5 | 3.64 | .270 | 1.07 | 7.7 | 2.0 | 10.3 | 106.1 | 91 | 52 | 43 | 15 | 23 | 121 | 0 | 0 | 0 | 0 | 10 | 4 | 0 | 3.32 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 16 | 16 | 4 | 8 | 5.59 | .325 | 1.42 | 10.3 | 2.4 | 4.3 | 114.1 | 131 | 77 | 71 | 15 | 31 | 54 | 1 | 0 | 0 | 0 | 4 | 3 | 2 | 4.66 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 70 | 15 | 15 | 6 | 7 | 5.15 | .336 | 1.51 | 10.9 | 2.7 | 6.3 | 99.2 | 120 | 61 | 57 | 12 | 30 | 69 | 0 | 0 | 0 | 0 | 6 | 1 | 5 | 4.12 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 42 | 0 | 5 | 2 | 2.47 | .244 | 0.95 | 5.8 | 2.8 | 9.0 | 54.2 | 35 | 15 | 15 | 3 | 17 | 54 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 2.72 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 33 | 0 | 3 | 4 | 4.00 | .308 | 1.33 | 9.0 | 3.0 | 6.6 | 45.0 | 45 | 20 | 20 | 4 | 15 | 33 | 0 | 2 | 3 | 0 | 0 | 0 | 0 | 3.69 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 33 | 0 | 1 | 2 | 4.08 | .325 | 1.42 | 9.3 | 3.6 | 8.0 | 35.1 | 36 | 16 | 16 | 3 | 14 | 31 | 0 | 5 | 1 | 0 | 0 | 1 | 0 | 3.63 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 58 | 1 | 0 | 0 | 0 | 9.64 | .440 | 2.36 | 18.0 | 6.8 | 4.5 | 4.2 | 8 | 5 | 5 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.25 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 9 | 0 | 3 | 1 | 0.49 | .276 | 1.15 | 4.0 | 6.5 | 6.0 | 18.1 | 8 | 5 | 1 | 0 | 13 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.83 |