| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 13 | 13 | 5 | 6 | 4.20 | .285 | 1.17 | 8.9 | 1.7 | 9.8 | 83.2 | 82 | 43 | 39 | 9 | 16 | 90 | 1 | 0 | 0 | 0 | 5 | 2 | 0 | 2.89 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 13 | 13 | 8 | 0 | 4.02 | .313 | 1.35 | 9.0 | 3.3 | 8.9 | 80.2 | 80 | 40 | 36 | 10 | 29 | 79 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 3.78 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 12 | 12 | 4 | 3 | 5.91 | .356 | 1.63 | 11.1 | 3.5 | 9.5 | 67.0 | 83 | 52 | 44 | 14 | 26 | 71 | 1 | 0 | 0 | 0 | 4 | 2 | 0 | 4.85 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 29 | 0 | 3 | 1 | 3.63 | .311 | 1.33 | 7.1 | 5.0 | 12.2 | 34.2 | 27 | 19 | 14 | 4 | 19 | 46 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 3.59 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 19 | 0 | 1 | 1 | 4.26 | .345 | 1.58 | 10.9 | 3.3 | 11.8 | 19.0 | 23 | 9 | 9 | 4 | 7 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.21 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 25 | 0 | 2 | 0 | 3.34 | .326 | 1.45 | 6.8 | 6.5 | 9.0 | 29.2 | 22 | 11 | 11 | 2 | 21 | 29 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.07 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 15 | 0 | 1 | 0 | 3.29 | .379 | 1.83 | 9.7 | 7.6 | 11.8 | 13.2 | 14 | 6 | 5 | 0 | 11 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.92 |