| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 12 | 12 | 7 | 3 | 4.12 | .322 | 1.38 | 9.5 | 3.0 | 8.7 | 89.2 | 94 | 45 | 41 | 14 | 30 | 86 | 1 | 0 | 0 | 1 | 6 | 4 | 0 | 4.26 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 12 | 12 | 4 | 5 | 4.97 | .306 | 1.32 | 9.2 | 2.7 | 7.8 | 83.1 | 85 | 49 | 46 | 12 | 25 | 72 | 0 | 0 | 0 | 0 | 7 | 0 | 0 | 4.05 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 12 | 12 | 5 | 2 | 4.36 | .316 | 1.37 | 9.2 | 3.2 | 9.2 | 74.1 | 76 | 38 | 36 | 10 | 26 | 76 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.80 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 12 | 12 | 5 | 7 | 5.63 | .318 | 1.39 | 9.7 | 2.8 | 5.1 | 80.0 | 86 | 51 | 50 | 11 | 25 | 45 | 2 | 0 | 0 | 0 | 5 | 1 | 0 | 4.64 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 31 | 0 | 0 | 1 | 3.48 | .263 | 1.07 | 7.2 | 2.5 | 8.6 | 44.0 | 35 | 20 | 17 | 3 | 12 | 42 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 2.80 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 30 | 0 | 2 | 2 | 1.22 | .229 | 0.86 | 6.3 | 1.5 | 9.2 | 37.0 | 26 | 5 | 5 | 1 | 6 | 38 | 0 | 7 | 0 | 0 | 0 | 1 | 0 | 1.86 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 15 | 0 | 1 | 0 | 5.63 | .324 | 1.44 | 7.9 | 5.1 | 6.2 | 16.0 | 14 | 10 | 10 | 2 | 9 | 11 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.94 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 16 | 0 | 0 | 0 | 5.50 | .325 | 1.44 | 8.5 | 4.5 | 9.0 | 18.0 | 17 | 13 | 11 | 4 | 9 | 18 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.39 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 1 | 0 | 0 | 0 | 0.00 | .000 | 0.00 | - | - | - | 0.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |