| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 35 | 35 | 18 | 12 | 4.07 | .289 | 1.21 | 7.7 | 3.1 | 8.6 | 272.0 | 234 | 131 | 123 | 34 | 95 | 261 | 14 | 0 | 0 | 2 | 17 | 3 | 8 | 3.79 |
| SP | Hughes, T.Hughes, Tom # >> | 31 | 1915 | R | 64 | 33 | 33 | 8 | 17 | 5.04 | .311 | 1.34 | 9.0 | 3.1 | 4.6 | 182.0 | 182 | 108 | 102 | 20 | 62 | 94 | 0 | 0 | 0 | 0 | 11 | 3 | 2 | 4.47 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 31 | 31 | 2 | 11 | 5.16 | .333 | 1.49 | 8.7 | 4.7 | 8.9 | 136.0 | 132 | 85 | 78 | 21 | 71 | 134 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 4.63 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 93 | 0 | 10 | 3 | 3.62 | .271 | 1.09 | 7.6 | 2.2 | 9.0 | 124.1 | 105 | 52 | 50 | 20 | 30 | 124 | 0 | 4 | 3 | 0 | 0 | 4 | 1 | 3.92 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 96 | 0 | 9 | 6 | 5.05 | .333 | 1.49 | 9.1 | 4.4 | 8.3 | 130.0 | 131 | 75 | 73 | 23 | 63 | 120 | 0 | 10 | 7 | 0 | 0 | 1 | 0 | 4.93 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 77 | 0 | 6 | 4 | 3.76 | .348 | 1.58 | 6.9 | 7.3 | 8.0 | 91.0 | 70 | 42 | 38 | 11 | 74 | 81 | 0 | 10 | 4 | 0 | 0 | 2 | 6 | 5.30 |
| RP | Messersmith, A.Messersmith, Andy † >> | 23 | 1968 | R | 58 | 62 | 0 | 8 | 2 | 2.68 | .281 | 1.14 | 5.7 | 4.7 | 7.5 | 100.2 | 63 | 33 | 30 | 8 | 52 | 83 | 0 | 11 | 3 | 0 | 0 | 3 | 1 | 4.03 |