| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 6 | 6 | 1 | 3 | 4.75 | .308 | 1.33 | 10.0 | 2.0 | 8.3 | 36.0 | 40 | 21 | 19 | 6 | 8 | 33 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.00 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 6 | 6 | 0 | 3 | 5.60 | .316 | 1.36 | 9.8 | 2.6 | 9.3 | 35.1 | 38 | 25 | 22 | 7 | 10 | 36 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 4.49 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 5 | 5 | 1 | 2 | 3.86 | .345 | 1.58 | 9.9 | 4.5 | 7.5 | 30.1 | 33 | 13 | 13 | 5 | 15 | 25 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 5.00 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 46 | 5 | 5 | 3 | 1 | 5.40 | .304 | 1.28 | 7.3 | 4.5 | 8.0 | 26.2 | 21 | 18 | 16 | 5 | 13 | 23 | 1 | 0 | 0 | 0 | 3 | 1 | 0 | 5.35 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 16 | 0 | 1 | 0 | 4.03 | .302 | 1.30 | 9.8 | 2.0 | 10.2 | 22.1 | 24 | 10 | 10 | 6 | 5 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.95 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 15 | 0 | 3 | 0 | 2.66 | .220 | 0.80 | 5.5 | 2.0 | 8.6 | 23.2 | 14 | 7 | 7 | 2 | 5 | 22 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.00 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 11 | 0 | 1 | 0 | 3.45 | .288 | 1.15 | 9.0 | 1.8 | 9.0 | 15.2 | 15 | 6 | 6 | 1 | 3 | 15 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2.67 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 11 | 0 | 0 | 1 | 5.93 | .293 | 1.24 | 7.6 | 4.2 | 10.4 | 13.2 | 11 | 9 | 9 | 3 | 6 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.08 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 8 | 0 | 2 | 1 | 3.07 | .302 | 1.30 | 9.0 | 3.2 | 4.5 | 14.2 | 14 | 6 | 5 | 2 | 5 | 7 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.93 |