| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 10 | 15 | 4.32 | .305 | 1.30 | 9.4 | 2.3 | 9.0 | 204.0 | 214 | 105 | 98 | 27 | 51 | 204 | 1 | 0 | 0 | 0 | 18 | 3 | 0 | 3.51 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 32 | 32 | 8 | 14 | 4.87 | .309 | 1.33 | 9.5 | 2.5 | 8.5 | 196.0 | 206 | 115 | 106 | 34 | 55 | 185 | 3 | 0 | 0 | 1 | 15 | 2 | 4 | 4.24 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 32 | 32 | 13 | 10 | 4.74 | .322 | 1.39 | 9.3 | 3.3 | 5.9 | 172.2 | 177 | 97 | 91 | 26 | 63 | 112 | 0 | 0 | 0 | 0 | 15 | 6 | 1 | 4.87 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 46 | 31 | 31 | 18 | 5 | 3.90 | .324 | 1.42 | 8.4 | 4.5 | 8.2 | 184.2 | 171 | 94 | 80 | 22 | 92 | 167 | 1 | 0 | 0 | 0 | 19 | 2 | 2 | 4.27 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 92 | 0 | 5 | 2 | 4.89 | .306 | 1.28 | 8.7 | 2.9 | 8.6 | 123.1 | 119 | 70 | 67 | 18 | 39 | 117 | 0 | 7 | 4 | 0 | 0 | 5 | 7 | 4.07 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 84 | 0 | 9 | 4 | 5.71 | .313 | 1.34 | 8.8 | 3.3 | 9.7 | 110.1 | 108 | 72 | 70 | 20 | 40 | 118 | 0 | 6 | 4 | 0 | 0 | 3 | 0 | 4.39 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 71 | 0 | 3 | 5 | 3.54 | .282 | 1.16 | 7.3 | 3.1 | 7.7 | 81.1 | 66 | 33 | 32 | 11 | 28 | 69 | 0 | 11 | 1 | 0 | 0 | 2 | 0 | 4.17 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 53 | 0 | 0 | 3 | 4.52 | .298 | 1.26 | 6.4 | 5.0 | 9.4 | 63.2 | 45 | 33 | 32 | 3 | 35 | 66 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 3.24 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 40 | 0 | 4 | 4 | 6.99 | .381 | 1.83 | 12.0 | 4.6 | 4.9 | 64.1 | 85 | 55 | 50 | 9 | 33 | 35 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 5.33 |