| SP | Burnes, C.Burnes, Corbin >> | 26 | 2021 | R | 95 | 33 | 33 | 13 | 13 | 4.16 | .299 | 1.27 | 8.8 | 2.6 | 9.4 | 205.1 | 200 | 101 | 95 | 22 | 60 | 214 | 1 | 0 | 0 | 1 | 22 | 3 | 3 | 3.23 |
| SP | Peralta, F.Peralta, Freddy >> | 25 | 2021 | R | 96 | 32 | 32 | 14 | 9 | 3.68 | .304 | 1.29 | 6.7 | 4.9 | 9.9 | 181.0 | 134 | 76 | 74 | 14 | 99 | 200 | 0 | 0 | 0 | 0 | 21 | 4 | 3 | 3.50 |
| SP | Woodruff, B.Woodruff, Brandon # >> | 28 | 2021 | R | 93 | 31 | 31 | 11 | 12 | 4.18 | .294 | 1.23 | 8.8 | 2.3 | 8.9 | 161.2 | 157 | 79 | 75 | 13 | 42 | 160 | 0 | 0 | 0 | 0 | 16 | 3 | 2 | 2.90 |
| SP | Chacin, J.Chacin, Jhoulys >> | 30 | 2018 | R | 58 | 31 | 31 | 13 | 9 | 4.18 | .329 | 1.43 | 9.2 | 3.6 | 6.3 | 161.1 | 165 | 77 | 75 | 21 | 65 | 113 | 0 | 0 | 0 | 0 | 11 | 7 | 3 | 4.63 |
| SP | Higuera, T.Higuera, Teddy >> | 29 | 1987 | L | 35 | 33 | 30 | 12 | 12 | 3.98 | .320 | 1.38 | 9.4 | 3.1 | 7.4 | 203.2 | 213 | 99 | 90 | 27 | 69 | 166 | 3 | 0 | 0 | 0 | 14 | 5 | 4 | 4.19 |
| CL | Hader, J.Hader, Josh † >> | 27 | 2021 | L | 99 | 86 | 0 | 6 | 6 | 2.97 | .262 | 1.03 | 5.6 | 3.6 | 9.7 | 94.0 | 59 | 34 | 31 | 4 | 38 | 101 | 0 | 43 | 2 | 0 | 0 | 3 | 3 | 2.71 |
| SU | Jeffress, J.Jeffress, Jeremy >> | 30 | 2018 | R | 89 | 90 | 0 | 3 | 6 | 2.66 | .307 | 1.28 | 7.7 | 3.9 | 7.8 | 101.2 | 86 | 35 | 30 | 6 | 44 | 87 | 0 | 1 | 4 | 0 | 0 | 5 | 9 | 3.50 |
| RP | Knebel, C.Knebel, Corey >> | 26 | 2018 | R | 77 | 96 | 0 | 4 | 2 | 3.45 | .319 | 1.39 | 7.6 | 4.9 | 9.8 | 99.0 | 84 | 39 | 38 | 14 | 54 | 108 | 0 | 2 | 6 | 0 | 0 | 1 | 0 | 4.32 |
| RP | Fingers, R.Fingers, Rollie >> | 36 | 1982 | R | 65 | 82 | 0 | 7 | 1 | 4.92 | .309 | 1.30 | 8.2 | 3.5 | 6.8 | 97.0 | 88 | 57 | 53 | 18 | 38 | 73 | 0 | 4 | 1 | 0 | 0 | 4 | 3 | 5.21 |