| SP | Rodon, C.Rodon, Carlos >> | 28 | 2021 | L | 97 | 26 | 26 | 10 | 12 | 4.88 | .316 | 1.37 | 8.3 | 4.1 | 11.3 | 134.2 | 123 | 73 | 73 | 19 | 61 | 168 | 0 | 0 | 0 | 0 | 10 | 3 | 7 | 3.77 |
| SP | Pizarro, J.Pizarro, Juan # >> | 27 | 1964 | L | 84 | 26 | 26 | 10 | 12 | 3.71 | .297 | 1.24 | 8.4 | 2.8 | 6.3 | 179.1 | 168 | 82 | 74 | 21 | 55 | 126 | 6 | 0 | 0 | 0 | 17 | 4 | 3 | 4.11 |
| SP | Giolito, L.Giolito, Lucas >> | 26 | 2021 | R | 76 | 25 | 25 | 5 | 12 | 6.28 | .348 | 1.58 | 10.7 | 3.6 | 9.5 | 130.1 | 154 | 94 | 91 | 27 | 52 | 137 | 0 | 0 | 0 | 0 | 7 | 3 | 4 | 4.86 |
| SP | Peters, G.Peters, Gary >> | 27 | 1964 | L | 60 | 22 | 22 | 10 | 7 | 5.02 | .315 | 1.36 | 8.6 | 3.7 | 5.8 | 150.2 | 144 | 87 | 84 | 24 | 61 | 97 | 4 | 0 | 0 | 0 | 7 | 3 | 4 | 5.07 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 99 | 40 | 0 | 2 | 5 | 3.61 | .298 | 1.20 | 6.4 | 4.5 | 10.7 | 42.1 | 30 | 17 | 17 | 6 | 21 | 50 | 0 | 28 | 3 | 0 | 0 | 3 | 2 | 4.19 |
| SU | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 94 | 37 | 0 | 0 | 1 | 2.31 | .228 | 0.86 | 5.1 | 2.6 | 9.5 | 35.0 | 20 | 9 | 9 | 4 | 10 | 37 | 0 | 4 | 2 | 0 | 0 | 1 | 1 | 3.31 |
| RP | Fisher, E.Fisher, Eddie >> | 28 | 1964 | R | 84 | 61 | 0 | 7 | 1 | 4.01 | .298 | 1.25 | 8.3 | 3.0 | 6.7 | 107.2 | 99 | 52 | 48 | 18 | 36 | 80 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.76 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 42 | 1964 | R | 82 | 46 | 0 | 3 | 1 | 4.81 | .355 | 1.57 | 9.9 | 4.3 | 5.1 | 67.1 | 74 | 40 | 36 | 16 | 32 | 38 | 0 | 2 | 2 | 0 | 0 | 5 | 3 | 6.63 |
| RP | Foulke, K.Foulke, Keith >> | 28 | 2000 | R | 77 | 31 | 0 | 3 | 1 | 4.36 | .308 | 1.30 | 9.3 | 2.5 | 10.4 | 33.0 | 34 | 17 | 16 | 5 | 9 | 38 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 3.58 |
| RP | Kopech, M.Kopech, Michael >> | 25 | 2021 | R | 58 | 25 | 0 | 2 | 2 | 5.87 | .352 | 1.60 | 9.9 | 4.8 | 12.3 | 30.2 | 33 | 20 | 20 | 5 | 16 | 41 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.13 |