| SP | Rodon, C.Rodon, Carlos >> | 28 | 2021 | L | 96 | 26 | 26 | 9 | 7 | 4.55 | .290 | 1.20 | 7.7 | 3.1 | 10.8 | 156.1 | 134 | 82 | 79 | 27 | 53 | 187 | 2 | 0 | 0 | 1 | 11 | 5 | 2 | 3.97 |
| RP | Bummer, A.Bummer, Aaron >> | 27 | 2021 | L | 54 | 73 | 0 | 3 | 3 | 2.79 | .306 | 1.30 | 7.1 | 4.7 | 11.3 | 48.1 | 38 | 15 | 15 | 2 | 25 | 60 | 0 | 3 | 1 | 0 | 0 | 1 | 3 | 2.67 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 95 | 62 | 0 | 4 | 3 | 3.05 | .314 | 1.35 | 7.4 | 4.8 | 12.2 | 62.0 | 51 | 21 | 21 | 6 | 33 | 84 | 0 | 7 | 1 | 0 | 0 | 1 | 7 | 3.19 |
| RP | Hendriks, L.Hendriks, Liam >> | 32 | 2021 | R | 96 | 48 | 0 | 1 | 2 | 4.62 | .290 | 1.18 | 8.1 | 2.7 | 9.4 | 50.2 | 45 | 26 | 26 | 11 | 15 | 52 | 0 | 8 | 2 | 0 | 0 | 2 | 7 | 4.80 |
| RP | Hernandez, R.Hernandez, Roberto >> | 28 | 1992 | R | 88 | 29 | 0 | 2 | 3 | 3.75 | .299 | 1.25 | 6.8 | 4.5 | 6.3 | 36.0 | 27 | 15 | 15 | 3 | 18 | 25 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.28 |
| RP | Lopez, R.Lopez, Reynaldo >> | 27 | 2021 | R | 79 | 52 | 0 | 7 | 2 | 4.80 | .316 | 1.32 | 9.4 | 2.6 | 7.9 | 65.2 | 68 | 35 | 35 | 10 | 19 | 57 | 0 | 3 | 2 | 0 | 0 | 4 | 1 | 4.31 |
| RP | Tepera, R.Tepera, Ryan # >> | 33 | 2021 | R | 93 | 26 | 0 | 2 | 3 | 5.34 | .336 | 1.48 | 9.6 | 3.9 | 7.5 | 30.1 | 32 | 20 | 18 | 3 | 13 | 25 | 0 | 3 | 1 | 0 | 0 | 1 | 2 | 4.03 |