| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 95 | 15 | 15 | 2 | 9 | 4.83 | .301 | 1.28 | 9.1 | 2.5 | 8.5 | 87.2 | 88 | 56 | 47 | 13 | 24 | 82 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3.92 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 4 | 5 | 4.38 | .306 | 1.29 | 8.7 | 2.9 | 8.7 | 86.1 | 83 | 48 | 42 | 13 | 28 | 83 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 4.12 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 15 | 15 | 4 | 7 | 3.74 | .327 | 1.45 | 10.2 | 2.9 | 4.6 | 101.0 | 114 | 48 | 42 | 8 | 32 | 52 | 1 | 0 | 0 | 1 | 9 | 1 | 6 | 3.98 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 40 | 0 | 3 | 4 | 3.66 | .305 | 1.30 | 7.8 | 4.1 | 10.2 | 51.2 | 44 | 23 | 21 | 1 | 23 | 58 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 2.39 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 38 | 0 | 1 | 3 | 3.59 | .291 | 1.23 | 7.8 | 3.5 | 5.2 | 52.2 | 45 | 22 | 21 | 4 | 20 | 30 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 37 | 0 | 2 | 3 | 3.80 | .294 | 1.23 | 7.9 | 3.3 | 7.3 | 47.1 | 41 | 23 | 20 | 7 | 17 | 38 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 4.47 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 7 | 1 | 2 | 1 | 1.78 | .283 | 1.11 | 6.5 | 3.6 | 4.3 | 25.1 | 18 | 5 | 5 | 3 | 10 | 12 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 5.04 |
| SP | Russell, R.Russell, Reb >> | 27 | 1916 | L | 52 | 26 | 1 | 2 | 5 | 4.53 | .348 | 1.58 | 11.3 | 3.1 | 4.8 | 43.2 | 54 | 22 | 22 | 5 | 15 | 23 | 0 | 1 | 3 | 0 | 1 | 1 | 0 | 4.56 |